Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
LiCl   ClLi 42.39 GSK3b Galli C. (2013) Clin Oral Implants Res. 921-7.

WO2001074164
60
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
5.00 86
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
10.00 84
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
50.00 72
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
0.10 78
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239
Saitoh M. (1987) J. Biol. Chem. 262 7796
WO1999041984
20.00 66
ML-9, Hydrochloride   C15H17ClN2O2S • HCl 361.30 MLCK Reig J.A. (1993) Neurochem. Res. 18 317
Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045
WO1999041984
100.00 73
PD 184352 (CI-1040)   C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57

WO1998037881
1.00 82
PD 184352 (CI-1040)   C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57

WO1998037881
10.00 96
PI-103   C19H16N4O3 348.36 PI3K Samuels Y. (2004) Science 304 554

WO2001083456
1.00 103