Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
1.00 70
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
10.00 48
Sorafenib   C21H16ClF3N4O3 464.80 Raf, Multiple Tyrosine Kinases Targeted Lyons J.F. (2001) Endocrine Related Cancer 8 3 219-225
Wilhelm S.M. (2004) Cancer Res. 64(19) 7099-109
WO2002085857
10.00 34
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322


0.10 116
BI-D-1870   C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38

WO2003020722
0.10 76
BIRB-0796 (Doramapimod)   C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008

WO2004014387
1.00 78
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
10.00 6
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
1.00 8
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
10.00 2
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
0.01 26