Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
FMK (Caspase Inhibitor I)   C22H30FN3O7 467.50 Caspase Martin U. (2007) Apoptosis 12 525
Misaghi S. (2004) Chem. Biol. 11 1677
WO2001058526
3.00 75
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
0.10 48
Gö 6976   C24H18N4O 378.40 PKC Gschwendt M. (1996) FEBS Lett. 392 77
Wenzel-Seifert K. (1994) Biochem. Biophys. Res. Commun. 200 1536
WO2003009809
0.10 26
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
1.00 13
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
10.00 7
GW5074 (Raf1 Kinase Inhibitor I)   C15H8Br2INO2 520.90 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223

WO2010036813
1.00 92
GW5074 (Raf1 Kinase Inhibitor I)   C15H8Br2INO2 520.90 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223

WO2010036813
10.00 32
H-1152 (Rho Kinase Inhibitor)   C16H21N3O2S • 2HCl 392.30 ROCK Ikenoya M. (2002) J. Neurochem. 81 9
Sasaki Y. (2002) Pharmacol. Ther. 93 225
WO2010010702
1.00 19
H-7, Dihydrochloride   C14H17N3O2S • 2HCl 364.30 serine/threonine kinases Ku W.C. (1997) Biochem. Biophys. Res. Commun. 241 730
Jarvis W.D. (1994) Cancer Res. 54 1707
WO1999041984
10.00 61
H-8, Dihydrochloride   C12H15N3O2S • 2HCl 338.30 serine/threonine kinases Ido M. (1991) Br. J. Cancer 64 1103
Hagiwara M. (1987) Mol. Pharmacol. 31 523
WO1999041984
10.00 72