Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084


 1.00 71
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084


 10.00 42
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 7
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.


 10.00 1
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.


 1.00 10
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

10.00 88
UCN-01   C28H26N4O4 482.50 PKC Reinhardt H.C. (2007) Cancer Cell 11 175
Jiang X. (2004) Mol. Cancer Ther. 3 1221

0.01 70
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

5.00 87
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


 1.00 17
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


 10.00 7