Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

10.00 68
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

1.00 92
SB-216763   C19H12Cl2N2O2 371.22 GSK3 Coghlan (2000) Chem.Biol. 7 793
Liang (2006) J.Biol.Chem. 282 3904

10.00 52
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

10.00 70
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

2.00 89
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

10.00 70
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

20.00 49
Sirolimus   C51H79NO13 914.20 p70S6K, mTOR Powell D.J. (2003) Mol. Cell Biol. 23 7794
Braun W. (1995) FASEB J. 9 63

1.00 97
SL0101-1   C25H24O12 516.46 RSK Smith (2005) Cancer Res. 65 1027
Goden Sayeski (2006) Am. J. Cell. Physiol. 291 1308

10.00 76
SP600125 (JNK Inhibitor II, SAPK Inhibitor II)   C14H8N2O 220.20 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311
Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681

1.00 20