Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
Torin1 C35H28F3N5O2 607.62 mTOR Liu Q. (2012) J Biol Chem. 287 9742-52
Trametinib   C26H23FIN5O4 615.40 MEK
Trastuzumab EGFR
Trilaciclib   C24H30N8O 446.50 CDK4/6
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.
Tucatinib   C26H24N8O2 480.50 ERBB2
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472
UCN-01   C28H26N4O4 482.50 PKC Reinhardt H.C. (2007) Cancer Cell 11 175 Jiang X. (2004) Mol. Cancer Ther. 3 1221
Umbralisib   C31H24F3N5O3 571.50 PI3Kδ
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623 Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839
Upadacitinib   C17H19F3N6O 380.40 JAK1
Vandetanib   C22H24BrFN4O2 Multiple Tyrosine kinases targeted
Vemurafenib   C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9
Volasertib   C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102 Grinshtein N (2011) Cancer Res 71(4) 1385-1395
VPS34-IN1   C21H24ClN7O 425.91 Vps34 Bago R (2014) Biochem J.
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253
WNK-463   C21H24F3N7O2 463.46 WNK Yamada K (2016) Nat Chem Biol. 12(11) 896-898