Inhibitor | VPS34-IN2 (PIK-III)  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	95	8
AMPK (hum)	98	21
ASK1	100	9
Aurora A	96	11
Aurora B	65	8
BRK	84	3
BRSK1	91	0
BRSK2	105	4
BTK	104	2
CAMK1	103	3
CAMKK beta	100	3
CDK2-Cyclin A	78	9
CDK9-Cyclin T1	92	1
CHK1	98	9
CHK2	92	0
CK1 delta	92	1
CK1 gamma 2	105	21
CK2	97	5
CLK2	83	4
CSK	109	16
DAPK1	94	1
DDR2	85	20
DYRK1A	90	2
DYRK2	115	13
DYRK3	96	1
EF2K	103	9
EIF2AK3	110	5
EPH-A2	103	0
EPH-A4	100	2
EPH-B1	97	4
EPH-B2	100	14
EPH-B3	93	2
EPH-B4	99	9
ERK1	82	5
ERK2	91	1
ERK5	95	11
ERK8	53	2
FGF-R1	94	13
GCK	78	13
GSK3 beta	87	3
HER4	105	2
HIPK1	81	6
HIPK2	82	6
HIPK3	87	0
IGF-1R	76	3
IKK beta	93	4
IKK epsilon	83	5
IR	87	19
IRAK1	93	3
IRAK4	96	6
IRR	96	0
JAK2	73	2
JNK1	87	6
JNK2	82	6
JNK3	102	11
Lck	87	5
LKB1	92	1
MAP4K3	87	15
MAP4K5	87	10
MAPKAP-K2	96	2
MAPKAP-K3	94	1
MARK1	79	5
MARK2	93	10
MARK3	81	5
MARK4	95	5
MEKK1	83	2
MELK	88	3
MINK1	70	0
MKK1	83	0
MKK2	81	7
MKK6	86	11
MLK1	101	10
MLK3	78	4
MNK1	84	6
MNK2	95	6
MPSK1	105	8
MSK1	95	3
MST2	85	13
MST3	88	22
MST4	82	5
NEK2a	99	1
NEK6	95	1
NUAK1	90	3
OSR1	91	2
p38 alpha MAPK	101	3
p38 beta MAPK	88	9
p38 delta MAPK	89	2
p38 gamma MAPK	79	2
PAK2	96	4
PAK4	113	2
PAK5	84	3
PAK6	101	8
PDGFRA	89	6
PDK1	88	11
PHK	100	8
PIM1	90	8
PIM2	89	7
PIM3	93	3
PINK	92	5
PKA	94	6
PKB alpha	83	9
PKB beta	90	9
PKC alpha	86	5
PKC gamma	100	4
PKC zeta	101	4
PKD1	94	10
PLK1	86	13
PRAK	92	6
PRK2	81	1
RIPK2	85	3
ROCK 2	75	3
RSK1	86	11
RSK2	83	6
S6K1	82	6
SGK1	83	14
SIK2	85	1
SIK3	90	1
SmMLCK	95	2
Src	88	10
SRPK1	85	3
STK33	88	14
SYK	96	4
TAK1	77	7
TAO1	79	12
TBK1	93	8
TESK1	106	24
TGFBR1	82	13
TIE2	77	1
TLK1	93	10
TrkA	85	5
TSSK1	110	12
TTBK1	95	10
TTBK2	83	11
TTK	88	6
ULK1	83	3
ULK2	100	10
VEGFR1	97	7
WNK1	92	7
YES1	93	2
ZAP70	96	3

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	92	5
AMPK (hum)	82	8
ASK1	102	3
Aurora A	91	24
Aurora B	39	8
BRK	51	5
BRSK1	76	1
BRSK2	102	4
BTK	84	2
CAMK1	87	7
CAMKK beta	94	8
CDK2-Cyclin A	52	2
CDK9-Cyclin T1	76	1
CHK1	90	12
CHK2	94	6
CK1 delta	63	5
CK1 gamma 2	93	4
CK2	92	5
CLK2	67	11
CSK	136	39
DAPK1	85	5
DDR2	91	18
DYRK1A	85	0
DYRK2	96	18
DYRK3	88	7
EF2K	89	6
EIF2AK3	84	2
EPH-A2	92	1
EPH-A4	92	3
EPH-B1	90	7
EPH-B2	81	16
EPH-B3	97	8
EPH-B4	104	3
ERK1	91	7
ERK2	72	6
ERK5	70	1
ERK8	15	1
FGF-R1	85	5
GCK	73	1
GSK3 beta	67	9
HER4	86	14
HIPK1	74	1
HIPK2	78	4
HIPK3	87	4
IGF-1R	76	5
IKK beta	82	4
IKK epsilon	82	2
IR	79	12
IRAK1	88	3
IRAK4	68	9
IRR	90	7
JAK2	30	1
JNK1	77	13
JNK2	74	8
JNK3	92	7
Lck	83	0
LKB1	85	6
MAP4K3	78	7
MAP4K5	74	6
MAPKAP-K2	99	5
MAPKAP-K3	95	7
MARK1	64	3
MARK2	90	15
MARK3	70	8
MARK4	87	0
MEKK1	91	5
MELK	76	2
MINK1	64	8
MKK1	86	3
MKK2	80	3
MKK6	88	23
MLK1	81	13
MLK3	52	9
MNK1	76	10
MNK2	92	4
MPSK1	84	1
MSK1	86	1
MST2	69	4
MST3	78	4
MST4	74	1
NEK2a	99	4
NEK6	84	3
NUAK1	68	6
OSR1	90	1
p38 alpha MAPK	92	1
p38 beta MAPK	87	12
p38 delta MAPK	83	0
p38 gamma MAPK	76	1
PAK2	85	1
PAK4	75	9
PAK5	83	7
PAK6	93	7
PDGFRA	97	2
PDK1	90	3
PHK	101	7
PIM1	90	1
PIM2	94	6
PIM3	91	13
PINK	85	4
PKA	94	7
PKB alpha	83	11
PKB beta	96	5
PKC alpha	91	10
PKC gamma	94	11
PKC zeta	112	8
PKD1	89	10
PLK1	87	8
PRAK	87	2
PRK2	72	1
RIPK2	58	6
ROCK 2	78	7
RSK1	91	4
RSK2	75	9
S6K1	78	3
SGK1	94	1
SIK2	67	4
SIK3	79	4
SmMLCK	84	1
Src	87	10
SRPK1	81	5
STK33	89	6
SYK	92	4
TAK1	47	7
TAO1	48	6
TBK1	91	2
TESK1	81	6
TGFBR1	79	3
TIE2	72	14
TLK1	83	8
TrkA	92	24
TSSK1	81	3
TTBK1	81	7
TTBK2	87	13
TTK	84	1
ULK1	81	10
ULK2	98	10
VEGFR1	70	1
WNK1	96	7
YES1	80	11
ZAP70	93	5