Inhibitor | TTT-3002  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
TTT-3002   LRRK2 Yao C (2012) Hum Mol Genet.

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
ABL 98 6
AMPK
6
 0
AMPK (hum)
4
 1
ASK1 113 4
Aurora A 28 2
Aurora B 49 5
BRK 28 8
BRSK1 61 4
BRSK2 16 1
BTK 49 4
CAMK1 97 10
CAMKK beta 64 4
CDK2-Cyclin A 18 6
CDK9-Cyclin T1 61 19
CHK1 11 0
CHK2 24 5
CK1 delta 109 2
CK1 gamma 2 106 4
CK2 106 14
CLK2
9
 5
CSK 112 10
DAPK1 51 3
DDR2 81 20
DYRK1A 29 1
DYRK2 41 2
DYRK3 24 1
EF2K 105 6
EIF2AK3 62 2
EPH-A2 92 2
EPH-A4 95 9
EPH-B1 41 6
EPH-B2 108 8
EPH-B3 106 2
EPH-B4 102 2
ERK1 38 21
ERK2 22 0
ERK5 66 4
ERK8 48 1
FGF-R1 53 1
GCK
6
 0
GSK3 beta 51 11
HER4 96 16
HIPK1 98 5
HIPK2 85 3
HIPK3 83 9
IGF-1R 87 6
IKK beta 75 9
IKK epsilon
6
 0
IR 120 16
IRAK1 15 3
IRAK4
7
 1
IRR 47 0
JAK2
10
 3
JNK1 91 8
JNK2 101 12
JNK3 65 2
Lck 44 4
LKB1 103 1
MAP4K3
3
 0
MAP4K5
10
 2
MAPKAP-K2 19 3
MAPKAP-K3 91 8
MARK1 11 3
MARK2 11 0
MARK3
7
 0
MARK4
10
 2
MEKK1 97 1
MELK 18 5
MINK1
4
 0
MKK1
9
 5
MKK2 32 13
MKK6
10
 7
MLK1
3
 0
MLK3 17 3
MNK1 61 3
MNK2 93 4
MPSK1 102 4
MSK1 41 2
MST2 18 13
MST3 97 12
MST4 86 2
NEK2a 105 1
NEK6 87 5
NUAK1
2
 1
OSR1 75 10
p38 alpha MAPK 106 2
p38 beta MAPK 108 5
p38 delta MAPK 100 0
p38 gamma MAPK 76 2
PAK2 71 11
PAK4 25 14
PAK5 17 2
PAK6 29 5
PDGFRA 54 6
PDK1 17 1
PHK 17 21
PIM1 71 0
PIM2 93 2
PIM3 17 2
PKA 29 4
PKB alpha 93 3
PKB beta 109 1
PKC alpha 79 16
PKC gamma 95 4
PKC zeta 110 6
PKD1 21 6
PLK1 68 17
PRAK 81 0
PRK2 21 5
RIPK2 80 5
ROCK 2 82 5
RSK1
9
 1
RSK2 16 0
S6K1 37 6
SGK1 79 6
SIK2
4
 0
SIK3 31 5
SmMLCK 48 1
Src 78 5
SRPK1 89 4
STK33 44 10
SYK 21 2
TAK1 111 16
TAO1 53 6
TBK1 22 12
TESK1 76 9
TGFBR1 96 3
TIE2 59 2
TLK1 93 4
TrkA
5
 0
TSSK1 13 1
TTBK1 101 8
TTBK2 107 8
TTK 37 2
ULK1 102 8
ULK2 30 1
VEGFR1 17 2
WNK1 103 26
YES1 76 9
ZAP70 83 0
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 82 8
AMPK
2
 0
AMPK (hum)
3
 3
ASK1 15 3
Aurora A
4
 0
Aurora B 46 1
BRK 16 4
BRSK1
3
 0
BRSK2
10
 1
BTK 11 4
CAMK1 25 1
CAMKK beta 14 2
CDK2-Cyclin A
9
 1
CDK9-Cyclin T1 17 1
CHK1
4
 1
CHK2
5
 0
CK1 delta 107 14
CK1 gamma 2 97 4
CK2 108 11
CLK2
-1
 1
CSK 73 6
DAPK1 18 1
DDR2
8
 1
DYRK1A
8
 1
DYRK2
9
 1
DYRK3
4
 1
EF2K 97 14
EIF2AK3 59 8
EPH-A2 53 6
EPH-A4 61 4
EPH-B1 56 4
EPH-B2 89 13
EPH-B3 100 4
EPH-B4 60 2
ERK1
4
 1
ERK2
6
 1
ERK5 24 4
ERK8
8
 13
FGF-R1 22 4
GCK
4
 0
GSK3 beta 15 6
HER4 63 0
HIPK1 82 4
HIPK2 30 1
HIPK3 43 8
IGF-1R 64 12
IKK beta 24 0
IKK epsilon
1
 4
IR 76 16
IRAK1
2
 2
IRAK4
7
 2
IRR 12 2
JAK2 12 8
JNK1
4
 1
JNK2 98 9
JNK3 30 0
Lck 13 5
LKB1 50 3
MAP4K3
2
 1
MAP4K5
7
 1
MAPKAP-K2
0
 4
MAPKAP-K3 74 0
MARK1
5
 1
MARK2
5
 0
MARK3
3
 2
MARK4
2
 0
MEKK1 78 11
MELK
10
 2
MINK1
3
 1
MKK1
0
 1
MKK2 17 14
MKK6 13 11
MLK1
2
 0
MLK3
5
 0
MNK1 16 0
MNK2 12 2
MPSK1 85 5
MSK1
10
 1
MST2 16 8
MST3 50 2
MST4 26 3
NEK2a 105 8
NEK6 89 14
NUAK1
2
 0
OSR1 23 1
p38 alpha MAPK 109 3
p38 beta MAPK 96 6
p38 delta MAPK 97 0
p38 gamma MAPK 29 1
PAK2 19 3
PAK4
7
 5
PAK5
4
 0
PAK6
2
 0
PDGFRA
8
 1
PDK1
2
 1
PHK
1
 0
PIM1 16 1
PIM2 30 2
PIM3
10
 5
PKA
5
 1
PKB alpha 44 15
PKB beta 51 0
PKC alpha 44 9
PKC gamma 51 2
PKC zeta 56 2
PKD1 17 4
PLK1 38 5
PRAK 15 1
PRK2
8
 2
RIPK2 26 3
ROCK 2 49 39
RSK1
3
 1
RSK2
7
 1
S6K1
6
 1
SGK1 32 1
SIK2
0
 0
SIK3
7
 4
SmMLCK
4
 2
Src 19 3
SRPK1 53 2
STK33 27 3
SYK
6
 2
TAK1
2
 1
TAO1 15 5
TBK1 16 11
TESK1 19 4
TGFBR1 74 1
TIE2 41 1
TLK1 39 4
TrkA
3
 0
TSSK1
5
 2
TTBK1 108 4
TTBK2 102 17
TTK 13 1
ULK1 43 0
ULK2
5
 1
VEGFR1 13 10
WNK1 91 9
YES1 20 4
ZAP70 16 6
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 37 0
AMPK
1
 0
AMPK (hum)
1
 1
ASK1
2
 0
Aurora A
5
 1
Aurora B 39 3
BRK
4
 1
BRSK1
1
 0
BRSK2
8
 2
BTK
9
 9
CAMK1
4
 1
CAMKK beta 11 3
CDK2-Cyclin A
8
 2
CDK9-Cyclin T1 15 8
CHK1
3
 1
CHK2
2
 0
CK1 delta 96 3
CK1 gamma 2 86 10
CK2 80 5
CLK2
-1
 1
CSK 20 2
DAPK1
4
 2
DDR2
3
 1
DYRK1A
3
 1
DYRK2
4
 1
DYRK3
2
 0
EF2K 79 9
EIF2AK3 36 6
EPH-A2 19 3
EPH-A4 16 2
EPH-B1 25 12
EPH-B2 34 4
EPH-B3 83 4
EPH-B4
8
 1
ERK1
2
 1
ERK2
5
 0
ERK5 12 1
ERK8 11 4
FGF-R1
3
 0
GCK
2
 1
GSK3 beta
7
 1
HER4 14 4
HIPK1 22 1
HIPK2
6
 0
HIPK3
10
 0
IGF-1R
3
 0
IKK beta
6
 1
IKK epsilon
2
 3
IR 11 5
IRAK1
3
 1
IRAK4
4
 0
IRR
9
 1
JAK2
7
 0
JNK1
1
 0
JNK2
4
 0
JNK3 26 4
Lck
3
 3
LKB1 35 1
MAP4K3
1
 1
MAP4K5
4
 2
MAPKAP-K2
-1
 2
MAPKAP-K3 29 2
MARK1
5
 2
MARK2
4
 1
MARK3
2
 1
MARK4
1
 0
MEKK1 23 6
MELK
5
 2
MINK1
2
 0
MKK1
0
 1
MKK2 14 3
MKK6
5
 4
MLK1
2
 1
MLK3
3
 0
MNK1
9
 2
MNK2
10
 6
MPSK1 69 2
MSK1
2
 0
MST2
9
 9
MST3
6
 2
MST4 20 5
NEK2a 66 1
NEK6 72 9
NUAK1
1
 1
OSR1
7
 0
p38 alpha MAPK 105 8
p38 beta MAPK 79 5
p38 delta MAPK 48 3
p38 gamma MAPK
6
 3
PAK2
4
 1
PAK4
7
 9
PAK5
2
 0
PAK6
1
 0
PDGFRA
2
 3
PDK1
2
 0
PHK
1
 0
PIM1
1
 0
PIM2
4
 1
PIM3
10
 2
PKA
2
 0
PKB alpha
5
 1
PKB beta
8
 0
PKC alpha 23 20
PKC gamma 13 1
PKC zeta 15 0
PKD1 16 4
PLK1 22 3
PRAK
2
 0
PRK2
6
 4
RIPK2
9
 1
ROCK 2
7
 1
RSK1
1
 0
RSK2
6
 0
S6K1
3
 0
SGK1
10
 1
SIK2
1
 1
SIK3
2
 2
SmMLCK
1
 1
Src
6
 1
SRPK1 11 0
STK33 23 3
SYK
2
 1
TAK1
2
 0
TAO1
7
 1
TBK1 12 9
TESK1
2
 0
TGFBR1 17 1
TIE2 20 14
TLK1
6
 0
TrkA
2
 1
TSSK1
4
 1
TTBK1 99 0
TTBK2 90 10
TTK
7
 1
ULK1 11 0
ULK2
1
 0
VEGFR1
4
 5
WNK1 86 12
YES1
2
 0
ZAP70
2
 0