Inhibitor | Vemurafenib  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	96	0
AMPK	79	1
ASK1	101	11
Aurora A	102	8
Aurora B	96	26
BRK	27	8
BRSK1	101	2
BRSK2	90	5
BTK	82	7
CAMK1	87	18
CAMKK beta	96	12
CDK2-Cyclin A	81	14
CHK1	98	5
CHK2	93	4
CK1 delta	94	7
CK2	74	7
CLK2	95	5
CSK	23	2
DAPK1	91	3
DYRK1A	85	2
DYRK2	100	4
DYRK3	92	1
EF2K	90	6
EIF2AK3	78	0
EPH-A2	88	9
EPH-A4	92	10
EPH-B1	111	29
EPH-B2	92	6
EPH-B3	102	14
EPH-B4	101	11
ERK1	94	8
ERK2	106	11
ERK8	107	21
FGF-R1	96	16
GCK	40	16
GSK3 beta	85	23
HER4	65	4
HIPK1	97	17
HIPK2	92	3
HIPK3	89	1
IGF-1R	82	14
IKK beta	95	2
IKK epsilon	94	3
IR	60	11
IRAK1	105	4
IRAK4	93	5
IRR	105	8
JAK2	81	4
JNK1	71	5
JNK2	87	4
JNK3	94	15
Lck	32	1
LKB1	97	10
MAPKAP-K2	115	1
MAPKAP-K3	93	7
MARK1	98	1
MARK2	102	8
MARK3	82	7
MARK4	79	1
MEKK1	98	10
MELK	99	32
MINK1	27	3
MKK1	77	7
MKK2	56	4
MKK6	138	0
MLK1	28	6
MLK3	75	3
MNK1	68	6
MNK2	85	6
MPSK1	85	0
MSK1	106	5
MST2	53	5
MST4	96	4
NEK2a	91	1
NEK6	93	1
NUAK1	80	3
OSR1	100	1
p38 alpha MAPK	74	1
p38 beta MAPK	73	6
p38 delta MAPK	86	7
p38 gamma MAPK	107	12
PAK2	92	5
PAK4	80	10
PAK5	90	3
PAK6	101	4
PDK1	106	13
PHK	90	4
PIM1	95	2
PIM2	96	1
PIM3	95	8
PKA	90	3
PKB alpha	110	8
PKB beta	91	3
PKC alpha	107	9
PKC gamma	95	8
PKC zeta	96	14
PKD1	76	0
PLK1	113	4
PRAK	90	13
PRK2	82	10
RIPK2	28	15
ROCK 2	86	7
RSK1	103	8
RSK2	79	14
S6K1	94	4
SGK1	101	4
SmMLCK	89	9
Src	32	16
SRPK1	95	4
STK33	86	5
SYK	104	4
TAK1	67	14
TAO1	117	0
TBK1	97	5
TESK1	47	3
TIE2	80	1
TLK1	102	6
TrkA	90	1
TSSK1	100	16
TTBK1	92	10
TTK	90	11
VEGFR1	48	1
YES1	37	3
ZAP70	103	7

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	93	1
AMPK	79	12
ASK1	105	10
Aurora A	98	6
Aurora B	97	23
BRK	42	16
BRSK1	107	9
BRSK2	99	2
BTK	86	1
CAMK1	14	4
CAMKK beta	99	9
CDK2-Cyclin A	90	5
CHK1	92	2
CHK2	84	7
CK1 delta	92	5
CK2	83	3
CLK2	103	11
CSK	50	4
DAPK1	90	8
DYRK1A	43	2
DYRK2	96	5
DYRK3	97	5
EF2K	79	12
EIF2AK3	76	11
EPH-A2	75	14
EPH-A4	91	5
EPH-B1	104	7
EPH-B2	94	1
EPH-B3	98	2
EPH-B4	86	15
ERK1	100	2
ERK2	91	4
ERK8	97	4
FGF-R1	110	10
GCK	79	3
GSK3 beta	83	13
HER4	85	2
HIPK1	102	4
HIPK2	92	7
HIPK3	82	7
IGF-1R	69	11
IKK beta	98	11
IKK epsilon	81	10
IR	82	10
IRAK1	98	0
IRAK4	92	6
IRR	95	12
JAK2	83	3
JNK1	89	9
JNK2	98	5
JNK3	90	10
Lck	17	2
LKB1	89	1
MAPKAP-K2	115	15
MAPKAP-K3	94	4
MARK1	99	9
MARK2	101	0
MARK3	88	5
MARK4	69	11
MEKK1	87	8
MELK	91	3
MINK1	10	11
MKK1	82	9
MKK2	75	5
MKK6	135	3
MLK1	89	1
MLK3	92	11
MNK1	107	7
MNK2	94	6
MPSK1	86	7
MSK1	100	5
MST2	89	6
MST4	93	4
NEK2a	77	5
NEK6	81	7
NUAK1	87	6
OSR1	105	6
p38 alpha MAPK	30	0
p38 beta MAPK	90	8
p38 delta MAPK	81	8
p38 gamma MAPK	102	17
PAK2	92	2
PAK4	86	14
PAK5	95	4
PAK6	98	2
PDK1	99	5
PHK	67	2
PIM1	94	7
PIM2	81	8
PIM3	96	1
PKA	99	13
PKB alpha	98	0
PKB beta	71	28
PKC alpha	100	9
PKC gamma	95	4
PKC zeta	98	7
PKD1	72	9
PLK1	102	1
PRAK	110	11
PRK2	83	6
RIPK2	52	12
ROCK 2	87	1
RSK1	60	0
RSK2	57	10
S6K1	102	3
SGK1	98	4
SmMLCK	54	5
Src	3	3
SRPK1	97	5
STK33	83	3
SYK	82	1
TAK1	73	5
TAO1	99	7
TBK1	97	1
TESK1	51	17
TIE2	82	4
TLK1	103	2
TrkA	97	21
TSSK1	95	5
TTBK1	98	15
TTK	94	4
VEGFR1	96	3
YES1	87	7
ZAP70	114	4