Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
0.10 107
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
1.00 89
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


1.00 130
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


0.10 118
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

10.00 20
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

1.00 80
SB-216763   C19H12Cl2N2O2 371.22 GSK3 Coghlan (2000) Chem.Biol. 7 793
Liang (2006) J.Biol.Chem. 282 3904

10.00 69
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

10.00 33
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

2.00 52
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


0.10 92