Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
1.00 99
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


1.00 5
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


10.00 1
Vemurafenib   C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9


10.00 79
Vemurafenib   C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9


1.00 79
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6

WO2011028540
10.00 56
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6

WO2011028540
0.10 91
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6

WO2011028540
1.00 114
PP1   C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695
Liu (1999) Chem.Biol. 6 671
WO2012109732
10.00 107
PP1   C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695
Liu (1999) Chem.Biol. 6 671
WO2012109732
0.10 99