Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 10.00 3
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 1.00 47
PS-1145   C17H11ClN4O 322.75 IKK Castro A.C. (2003) Bioorg. Med. Chem. Lett. 13 2419-2422.

WO2003039545
 10.00 88
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


0.10 101
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


1.00 93
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
 0.10 107
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
 1.00 74
Quercetagetin C15H10O8 318.30 PIM1 Holder S. (2007) Mol. Cancer Ther. 6 163


10.00 9
Quercetagetin C15H10O8 318.30 PIM1 Holder S. (2007) Mol. Cancer Ther. 6 163


1.00 73
Resveratrol   C14H12O3 228.20 cyclo-oxygenase 1 Lin H.Y. (2002) J. Urol. 168 748
Klabunde T. (2000) Nat. Struct. Biol. 7 312

1.00 103