Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

10.00 77
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

20.00 92
Sirolimus   C51H79NO13 914.20 p70S6K, mTOR Powell D.J. (2003) Mol. Cell Biol. 23 7794
Braun W. (1995) FASEB J. 9 63

1.00 87
SL-327 (MEK1-2 Inhibitor)   C16H12F3N3S 335.40 MEK1, MEK2 Hetman M. (2002) J. Biol. Chem. 277 49577
Ohno M. (2001) Nat. Neurosci. 4 1238

10.00 102
SL0101-1   C25H24O12 516.46 RSK Smith (2005) Cancer Res. 65 1027
Goden Sayeski (2006) Am. J. Cell. Physiol. 291 1308

10.00 88
Sodium salicylate   HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84


1.00 102
Sodium salicylate   HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84


10.00 88
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

50.00 91
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

1.00 98
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

10.00 94