Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962.
French (2006) J.Pharmacol.Exp.Ther. 318 596

1.00 81
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962.
French (2006) J.Pharmacol.Exp.Ther. 318 596

10.00 61
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084


1.00 5
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084


10.00 1
SRT 1720   C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716


10.00 80
SRT 1720   C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716


1.00 82
SRT 1720   C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716


0.10 69
Staurosporine C28H26N4O3 466.54 Broad spectrum Boix J. (1997) Neuropharmacology 36 811-821
Wiesner D.A. and Dawson G. (1996) J. Neurochem. 66 1418-1425

10.00 8
STO 609   C19H10N2O3 • CH3CO2H 374.40 CaMKK Levine Y. (2007) J. Biol. Chem. 282 20351
Tokumitsu H. (2003) J. Biol. Chem. 278 10908

1.00 97
STO 609   C19H10N2O3 • CH3CO2H 374.40 CaMKK Levine Y. (2007) J. Biol. Chem. 282 20351
Tokumitsu H. (2003) J. Biol. Chem. 278 10908

10.00 99