Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


0.10 30
SB-216763   C19H12Cl2N2O2 371.22 GSK3 Coghlan (2000) Chem.Biol. 7 793
Liang (2006) J.Biol.Chem. 282 3904

10.00 43
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

10.00 72
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793
Cross (2001) J.Neurochem. 77 94

2.00 79
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


1.00 92
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


0.10 112
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


10.00 86
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744


0.10 122
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744


1.00 105
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100


10.00 73