Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SYK Inhibitor II   C14H15F3N6O • 2HCl•2H2O 449.30 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936


 0.10 86
SYK Inhibitor III   C9H7NO4 193.20 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380


 1.00 91
SYK Inhibitor III   C9H7NO4 193.20 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380


 10.00 73
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 0.10 86
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 1.00 69
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 0.20 82
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 10.00 80
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

10.00 3
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

1.00 13
Tenovin-6   C25H34N4O2S 454.60

10.00 113