Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Kenpaullone   C16H11BrN2O 327.20 GSK, CDK Bain J. (2003) Biochem. J. 371 199
Buolamwini J.K. (2000) Curr. Pharm. Des. 6 379
WO2013184591
1.00 94
KIN 112   C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991


1.00 87
KIN 112   C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991


0.01 99
KIN 112   C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991


0.10 88
KN62   C38H35N5O6S2 721.90 CaMKII Minami H. (1994) Biochem. Biophys. Res. Commun. 199 241

US20080255244
10.00 115
KN93   C26H29CIN2O4S 501.00 CaMKII Fan G.H. (1999) Mol. Pharmacol. 56 39
Tombes R.M. (1995) Cell Growth Differ. 6 1063
WO2009042906
10.00 77
KN93   C26H29CIN2O4S 501.00 CaMKII Fan G.H. (1999) Mol. Pharmacol. 56 39
Tombes R.M. (1995) Cell Growth Differ. 6 1063
WO2009042906
1.00 88
KT5720   C32H31N3O5 537.60 PKA Simpson CS. Morris BJ. (1995) Neuroscience 68 97-106
Cabell L. Audesirk G. (1993) Int. J. Dev. Neurosci. 11 357
US20100216703
1.00 15
KU 0063794   C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42


1.00 97
KU 0063794   C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42


10.00 106