Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.01 105
IC261   C18H17NO4 311.30 CK1 Behrend L. (2000) Oncogene 19 5303
Mashhoon N. (2000) J. Biol. Chem. 275 20052
WO2008066626
 25.00 71
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 10.00 22
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 1.00 49
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373
Karin M. (2004) Nat. Rev. Drug Discov. 3 17
WO2008144011
 1.00 83
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373
Karin M. (2004) Nat. Rev. Drug Discov. 3 17
WO2008144011
 10.00 26
IKK-2 Inhibitor VIII   C21H24N4O2 364.40 IKK2 Murata T. (2004) Bioorg. Med. Chem. Lett. 14 4019


1.00 85
IKK-2 Inhibitor VIII   C21H24N4O2 364.40 IKK2 Murata T. (2004) Bioorg. Med. Chem. Lett. 14 4019


10.00 50
IKK-3 inhibitor IX   C22H19N3O5S2 469.50 IKK3 Bamborough P. (2006) Bioorg. Med. Chem. Lett. 16 6236

US20120134931
 1.00 10
IKK-3 inhibitor IX   C22H19N3O5S2 469.50 IKK3 Bamborough P. (2006) Bioorg. Med. Chem. Lett. 16 6236

US20120134931
 10.00 9