Inhibitor | KIN 112  

Screen Conc: 0.01µM

Kinase	% Activity Remaining	Standard Deviation
ABL	90	0
AMPK	99	14
ASK1	106	20
Aurora A	98	2
Aurora B	96	7
BRK	83	4
BRSK1	103	14
BRSK2	93	5
BTK	87	11
CAMK1	101	11
CAMKK beta	90	0
CDK2-Cyclin A	115	14
CDK9-Cyclin T1	106	4
CHK1	97	8
CHK2	94	10
CK1 delta	86	3
CK1 gamma 2	99	16
CK2	99	6
CLK2	110	1
CSK	117	15
DAPK1	85	3
DDR2	45	18
DYRK1A	95	15
DYRK2	94	10
DYRK3	91	4
EF2K	91	4
EIF2AK3	100	16
EPH-A2	57	3
EPH-A4	58	5
EPH-B1	68	4
EPH-B2	104	1
EPH-B3	121	8
EPH-B4	101	5
ERK1	101	1
ERK2	100	9
ERK8	104	10
FGF-R1	90	10
GCK	98	11
GSK3 beta	96	5
HER4	95	7
HIPK1	68	1
HIPK2	100	16
HIPK3	77	5
IGF-1R	126	0
IKK beta	86	4
IKK epsilon	99	13
IR	111	2
IRAK1	92	9
IRAK4	90	9
IRR	96	5
JAK2	91	4
JNK1	92	18
JNK2	103	23
JNK3	103	27
Lck	57	6
LKB1	110	7
MAPKAP-K2	95	5
MAPKAP-K3	99	30
MARK1	82	2
MARK2	100	30
MARK3	89	3
MARK4	96	28
MEKK1	96	20
MELK	102	5
MINK1	102	16
MKK1	100	10
MKK2	99	27
MKK6	98	7
MLK1	87	17
MLK3	87	27
MNK1	87	2
MNK2	100	7
MPSK1	109	10
MSK1	90	8
MST2	113	29
MST3	83	30
MST4	105	10
NEK2a	98	12
NEK6	82	11
NUAK1	98	11
OSR1	104	18
p38 alpha MAPK	118	9
p38 beta MAPK	113	10
p38 delta MAPK	97	14
p38 gamma MAPK	103	5
PAK2	79	8
PAK4	101	5
PAK5	103	0
PAK6	103	1
PDK1	97	5
PHK	108	22
PIM1	106	2
PIM2	91	5
PIM3	102	2
PKA	91	17
PKB alpha	95	6
PKB beta	85	12
PKC alpha	97	8
PKC gamma	92	15
PKC zeta	99	9
PKD1	95	8
PLK1	94	1
PRAK	138	28
PRK2	89	5
RIPK2	89	11
ROCK 2	99	13
RSK1	95	10
RSK2	98	5
S6K1	95	6
SGK1	93	7
SIK2	58	4
SIK3	89	3
SmMLCK	97	5
Src	45	8
SRPK1	86	9
STK33	113	28
SYK	103	4
TAK1	122	11
TAO1	98	10
TBK1	94	10
TESK1	80	6
TIE2	125	3
TLK1	94	0
TrkA	91	11
TSSK1	110	12
TTBK1	93	2
TTK	99	1
VEGFR1	89	13
WNK1	107	13
YES1	52	5
ZAP70	95	12

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	53	9
AMPK	88	4
ASK1	101	11
Aurora A	91	8
Aurora B	96	11
BRK	11	1
BRSK1	103	3
BRSK2	108	8
BTK	40	5
CAMK1	92	7
CAMKK beta	84	2
CDK2-Cyclin A	107	0
CDK9-Cyclin T1	90	4
CHK1	94	8
CHK2	65	8
CK1 delta	85	2
CK1 gamma 2	85	1
CK2	93	7
CLK2	97	2
CSK	92	18
DAPK1	80	7
DDR2	9	1
DYRK1A	101	10
DYRK2	88	9
DYRK3	91	17
EF2K	100	10
EIF2AK3	97	2
EPH-A2	16	2
EPH-A4	16	2
EPH-B1	14	11
EPH-B2	57	8
EPH-B3	70	2
EPH-B4	71	18
ERK1	113	19
ERK2	103	2
ERK8	92	6
FGF-R1	84	21
GCK	71	1
GSK3 beta	89	15
HER4	57	10
HIPK1	75	9
HIPK2	103	21
HIPK3	79	3
IGF-1R	97	24
IKK beta	107	1
IKK epsilon	108	0
IR	100	1
IRAK1	83	4
IRAK4	88	10
IRR	93	0
JAK2	91	6
JNK1	103	8
JNK2	92	1
JNK3	96	3
Lck	40	7
LKB1	106	1
MAPKAP-K2	101	8
MAPKAP-K3	88	16
MARK1	73	0
MARK2	90	5
MARK3	85	2
MARK4	101	8
MEKK1	90	17
MELK	100	5
MINK1	94	13
MKK1	93	1
MKK2	83	14
MKK6	104	3
MLK1	26	5
MLK3	62	10
MNK1	99	6
MNK2	104	3
MPSK1	110	6
MSK1	90	3
MST2	107	10
MST3	103	8
MST4	90	14
NEK2a	101	20
NEK6	93	8
NUAK1	88	7
OSR1	85	3
p38 alpha MAPK	115	1
p38 beta MAPK	99	9
p38 delta MAPK	93	18
p38 gamma MAPK	110	23
PAK2	65	12
PAK4	104	4
PAK5	89	5
PAK6	87	3
PDK1	103	5
PHK	103	3
PIM1	97	9
PIM2	88	31
PIM3	94	14
PKA	75	8
PKB alpha	94	2
PKB beta	75	8
PKC alpha	100	3
PKC gamma	102	5
PKC zeta	90	2
PKD1	83	17
PLK1	93	1
PRAK	116	2
PRK2	92	22
RIPK2	22	7
ROCK 2	104	13
RSK1	96	7
RSK2	97	2
S6K1	92	13
SGK1	98	16
SIK2	10	5
SIK3	37	9
SmMLCK	85	4
Src	10	2
SRPK1	94	6
STK33	99	12
SYK	114	17
TAK1	104	4
TAO1	92	7
TBK1	86	2
TESK1	52	15
TIE2	100	12
TLK1	89	10
TrkA	104	3
TSSK1	99	25
TTBK1	88	3
TTK	97	6
VEGFR1	77	5
WNK1	100	1
YES1	19	2
ZAP70	95	4

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	35	6
AMPK	87	1
ASK1	108	19
Aurora A	58	7
Aurora B	79	5
BRK	4	1
BRSK1	87	12
BRSK2	97	20
BTK	16	0
CAMK1	89	6
CAMKK beta	53	9
CDK2-Cyclin A	108	6
CDK9-Cyclin T1	96	9
CHK1	87	2
CHK2	33	3
CK1 delta	82	9
CK1 gamma 2	86	16
CK2	100	9
CLK2	100	6
CSK	36	6
DAPK1	87	5
DDR2	7	1
DYRK1A	92	12
DYRK2	100	2
DYRK3	90	18
EF2K	94	9
EIF2AK3	106	9
EPH-A2	8	1
EPH-A4	9	1
EPH-B1	2	0
EPH-B2	2	0
EPH-B3	24	1
EPH-B4	5	0
ERK1	98	8
ERK2	105	10
ERK8	85	11
FGF-R1	11	3
GCK	22	2
GSK3 beta	96	2
HER4	17	2
HIPK1	72	19
HIPK2	102	1
HIPK3	89	19
IGF-1R	112	38
IKK beta	88	25
IKK epsilon	110	15
IR	99	1
IRAK1	73	10
IRAK4	82	2
IRR	84	0
JAK2	69	2
JNK1	90	2
JNK2	88	10
JNK3	93	2
Lck	48	7
LKB1	100	2
MAPKAP-K2	98	20
MAPKAP-K3	74	2
MARK1	70	5
MARK2	88	11
MARK3	72	1
MARK4	112	3
MEKK1	58	14
MELK	109	2
MINK1	32	1
MKK1	78	4
MKK2	85	0
MKK6	108	14
MLK1	6	2
MLK3	17	0
MNK1	109	7
MNK2	96	12
MPSK1	103	6
MSK1	83	9
MST2	79	4
MST3	85	11
MST4	79	4
NEK2a	90	11
NEK6	94	5
NUAK1	53	3
OSR1	75	6
p38 alpha MAPK	87	1
p38 beta MAPK	75	7
p38 delta MAPK	97	5
p38 gamma MAPK	89	8
PAK2	44	0
PAK4	96	11
PAK5	86	12
PAK6	97	11
PDK1	100	7
PHK	54	6
PIM1	109	4
PIM2	100	58
PIM3	98	1
PKA	41	0
PKB alpha	84	20
PKB beta	64	4
PKC alpha	109	3
PKC gamma	109	1
PKC zeta	101	3
PKD1	65	10
PLK1	95	4
PRAK	122	8
PRK2	96	12
RIPK2	11	3
ROCK 2	85	11
RSK1	64	4
RSK2	77	5
S6K1	94	8
SGK1	95	1
SIK2	7	4
SIK3	7	1
SmMLCK	90	11
Src	3	0
SRPK1	90	0
STK33	96	3
SYK	68	4
TAK1	105	3
TAO1	72	1
TBK1	97	20
TESK1	20	10
TIE2	50	10
TLK1	86	9
TrkA	63	15
TSSK1	99	1
TTBK1	107	7
TTK	96	3
VEGFR1	30	8
WNK1	103	2
YES1	8	1
ZAP70	100	5