Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


1.00 85
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239
Saitoh M. (1987) J. Biol. Chem. 262 7796
WO1999041984
2.00 92
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239
Saitoh M. (1987) J. Biol. Chem. 262 7796
WO1999041984
20.00 78
ML-9, Hydrochloride   C15H17ClN2O2S • HCl 361.30 MLCK Reig J.A. (1993) Neurochem. Res. 18 317
Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045
WO1999041984
100.00 32
ML-9, Hydrochloride   C15H17ClN2O2S • HCl 361.30 MLCK Reig J.A. (1993) Neurochem. Res. 18 317
Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045
WO1999041984
10.00 85
MLN120B   C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273
Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705

10.00 92
MLN120B   C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273
Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705

30.00 74
MLN4924   C21H26ClN5O4S 479.98 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736


1.00 96
MLN4924   C21H26ClN5O4S 479.98 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736


10.00 99
MLN9708   C20H23BCl2N2O9 517.12 Proteasome Kupperman. E. (2010) Cancer Research 70 1970-1980


10.00 82