Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.


1.00 55
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

10.00 99
UCN-01   C28H26N4O4 482.50 PKC Reinhardt H.C. (2007) Cancer Cell 11 175
Jiang X. (2004) Mol. Cancer Ther. 3 1221

0.01 57
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

5.00 76
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


1.00 89
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


10.00 49
Wortmannin (KY 12420)   C23H24O8 428.40 PI3K Cross M.J. (1995) J. Biol. Chem. 270 25352
Nakamura I. (1995) FEBS Lett. 361 79

1.00 82
Y-27632   C14H21N3O • 2HCl • H2O 338.30 ROCK Watanabe K. (2007) Nature Biotech. 25 681
Chitaley K. (2001) Nat. Med. 7 119

10.00 107
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


10.00 101
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 57