Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
IC261   C18H17NO4 311.30 CK1 Behrend L. (2000) Oncogene 19 5303
Mashhoon N. (2000) J. Biol. Chem. 275 20052
WO2008066626
25.00 67
Kenpaullone   C16H11BrN2O 327.20 GSK, CDK Bain J. (2003) Biochem. J. 371 199
Buolamwini J.K. (2000) Curr. Pharm. Des. 6 379
WO2013184591
1.00 74
KN62   C38H35N5O6S2 721.90 CaMKII Minami H. (1994) Biochem. Biophys. Res. Commun. 199 241

US20080255244
10.00 85
KT5720   C32H31N3O5 537.60 PKA Simpson CS. Morris BJ. (1995) Neuroscience 68 97-106
Cabell L. Audesirk G. (1993) Int. J. Dev. Neurosci. 11 357
US20100216703
1.00 60
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
10.00 71
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
50.00 63
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
0.10 114
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239
Saitoh M. (1987) J. Biol. Chem. 262 7796
WO1999041984
20.00 82
ML-9, Hydrochloride   C15H17ClN2O2S • HCl 361.30 MLCK Reig J.A. (1993) Neurochem. Res. 18 317
Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045
WO1999041984
100.00 108
PD 184352 (CI-1040)   C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57

WO1998037881
1.00 87