Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
 1.00 99
CGP-57380   C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511
Proud C.G. (2005) Immunity 23 177-189
WO2010055072
 1.00 71
CGP-57380 analog (SHN-093)   C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189


 10.00 107
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
 0.01 104
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


 1.00 58
Sirolimus   C51H79NO13 914.20 p70S6K, mTOR Powell D.J. (2003) Mol. Cell Biol. 23 7794
Braun W. (1995) FASEB J. 9 63

1.00 77
Sunitinib   C22H27FN4O2 398.47 RTK, Multiple Tyrosine Kinases Targeted Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39


 1.00 102
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 91
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 111
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 50