Inhibitor |
CGP-57380 analog (SHN-093)
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
105
|
1
|
|
Aurora B
|
98
|
1
|
|
Aurora C
|
125
|
2
|
|
BRSK2
|
99
|
9
|
|
CAMK1
|
103
|
1
|
|
CAMKK alpha
|
89
|
3
|
|
CAMKK beta
|
112
|
10
|
|
CDK2-Cyclin A
|
98
|
3
|
|
CHK1
|
118
|
6
|
|
CHK2
|
103
|
1
|
|
CK1 delta
|
97
|
0
|
|
CK2
|
91
|
11
|
|
CSK
|
88
|
12
|
|
DYRK1A
|
105
|
2
|
|
DYRK2
|
86
|
7
|
|
DYRK3
|
119
|
1
|
|
EF2K
|
102
|
1
|
|
ERK1
|
124
|
6
|
|
ERK2
|
107
|
2
|
|
ERK8
|
76
|
8
|
|
GSK3 beta
|
119
|
10
|
|
HIPK2
|
113
|
0
|
|
HIPK3
|
143
|
1
|
|
IKK beta
|
98
|
2
|
|
JNK1
|
112
|
1
|
|
JNK2
|
122
|
5
|
|
JNK3
|
104
|
2
|
|
Lck
|
112
|
2
|
|
MAPKAP-K2
|
97
|
0
|
|
MAPKAP-K3
|
137
|
1
|
|
MARK3
|
82
|
3
|
|
MELK
|
109
|
2
|
|
MKK1
|
108
|
6
|
|
MNK1
|
95
|
6
|
|
MNK2
|
104
|
1
|
|
MSK1
|
97
|
1
|
|
MST2
|
102
|
6
|
|
NEK2a
|
102
|
1
|
|
NEK6
|
95
|
1
|
|
NEK7
|
94
|
8
|
|
p38 alpha MAPK
|
93
|
5
|
|
p38 beta MAPK
|
132
|
5
|
|
p38 delta MAPK
|
104
|
4
|
|
p38 gamma MAPK
|
113
|
3
|
|
PAK4
|
86
|
1
|
|
PAK5
|
109
|
4
|
|
PAK6
|
113
|
5
|
|
PDK1
|
92
|
5
|
|
PHK
|
113
|
9
|
|
PIM1
|
111
|
6
|
|
PIM2
|
100
|
2
|
|
PIM3
|
101
|
2
|
|
PKA
|
106
|
1
|
|
PKB alpha
|
124
|
4
|
|
PKB beta
|
103
|
3
|
|
PKC alpha
|
120
|
2
|
|
PKC zeta
|
97
|
4
|
|
PKD1
|
107
|
3
|
|
PLK1
|
92
|
0
|
|
PRAK
|
107
|
2
|
|
PRK2
|
103
|
8
|
|
ROCK 2
|
117
|
2
|
|
RSK1
|
121
|
4
|
|
RSK2
|
110
|
5
|
|
S6K1
|
114
|
0
|
|
SGK1
|
97
|
5
|
|
SmMLCK
|
94
|
9
|
|
Src
|
96
|
11
|
|
SRPK1
|
137
|
2
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
107
|
2
|
|
Aurora B
|
82
|
7
|
|
Aurora C
|
117
|
2
|
|
BRSK2
|
92
|
2
|
|
CAMK1
|
97
|
2
|
|
CAMKK alpha
|
112
|
1
|
|
CAMKK beta
|
120
|
6
|
|
CDK2-Cyclin A
|
96
|
1
|
|
CHK1
|
112
|
4
|
|
CHK2
|
96
|
4
|
|
CK1 delta
|
62
|
6
|
|
CK2
|
96
|
9
|
|
CSK
|
76
|
8
|
|
DYRK1A
|
101
|
2
|
|
DYRK2
|
83
|
4
|
|
DYRK3
|
101
|
0
|
|
EF2K
|
103
|
8
|
|
ERK1
|
111
|
5
|
|
ERK2
|
110
|
0
|
|
ERK8
|
70
|
3
|
|
GSK3 beta
|
125
|
1
|
|
HIPK2
|
105
|
0
|
|
HIPK3
|
136
|
8
|
|
IKK beta
|
96
|
3
|
|
JNK1
|
102
|
7
|
|
JNK2
|
124
|
5
|
|
JNK3
|
104
|
1
|
|
Lck
|
81
|
5
|
|
MAPKAP-K2
|
95
|
3
|
|
MAPKAP-K3
|
132
|
1
|
|
MARK3
|
79
|
4
|
|
MELK
|
91
|
1
|
|
MKK1
|
104
|
2
|
|
MNK1
|
92
|
0
|
|
MNK2
|
103
|
7
|
|
MSK1
|
84
|
2
|
|
MST2
|
104
|
4
|
|
NEK2a
|
100
|
8
|
|
NEK6
|
95
|
1
|
|
NEK7
|
99
|
5
|
|
p38 alpha MAPK
|
80
|
5
|
|
p38 beta MAPK
|
127
|
4
|
|
p38 delta MAPK
|
109
|
1
|
|
p38 gamma MAPK
|
112
|
1
|
|
PAK4
|
97
|
1
|
|
PAK5
|
125
|
4
|
|
PAK6
|
101
|
2
|
|
PDK1
|
106
|
5
|
|
PHK
|
119
|
1
|
|
PIM1
|
115
|
7
|
|
PIM2
|
109
|
9
|
|
PIM3
|
95
|
2
|
|
PKA
|
107
|
2
|
|
PKB alpha
|
106
|
3
|
|
PKB beta
|
103
|
1
|
|
PKC alpha
|
121
|
3
|
|
PKC zeta
|
102
|
2
|
|
PKD1
|
107
|
3
|
|
PLK1
|
94
|
3
|
|
PRAK
|
109
|
0
|
|
PRK2
|
109
|
1
|
|
ROCK 2
|
113
|
7
|
|
RSK1
|
102
|
5
|
|
RSK2
|
107
|
6
|
|
S6K1
|
114
|
4
|
|
SGK1
|
98
|
3
|
|
SmMLCK
|
107
|
3
|
|
Src
|
63
|
5
|
|
SRPK1
|
129
|
2
|
