Inhibitor | Akti 1/2  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Akti 1/2   C34H29N7O 551.60 612847-09-3 10196499 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27 Barnett S.F. (2005) Biochem. J. 385 399

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 96 14
Aurora B 83 5
Aurora C 83 0
BRSK2 93 0
CAMK1 90 3
CDK2-Cyclin A 92 3
CHK1 97 0
CHK2 83 7
CK1 delta 106 7
CK2 85 1
CSK 97 11
DYRK1A 97 11
DYRK2 105 3
DYRK3 87 6
EF2K 107 11
EPH-A2 95 6
ERK1 95 3
ERK2 71 15
ERK8 80 5
FGF-R1 89 8
GSK3 beta 83 3
HIPK2 98 6
HIPK3 72 2
IKK beta 91 11
IKK epsilon 107 7
IRR 91 3
JNK1 85 0
JNK2 95 0
JNK3 79 3
Lck 81 4
MAPKAP-K2 84 6
MAPKAP-K3 76 3
MARK3 86 1
MELK 86 10
MKK1 75 2
MNK1 81 0
MNK2 93 11
MSK1 84 2
MST2 103 0
MST4 92 1
NEK2a 92 6
NEK6 83 1
NEK7 86 0
p38 alpha MAPK 111 5
p38 beta MAPK 103 10
p38 delta MAPK 104 5
p38 gamma MAPK 110 7
PAK4 99 4
PAK5 87 7
PAK6 112 8
PDK1 91 9
PHK 104 1
PIM1 83 12
PIM2 95 6
PIM3 97 5
PKA 90 8
PKB alpha 85 3
PKB beta 101 6
PKC alpha 101 5
PKC zeta 101 0
PKD1 90 4
PLK1 83 2
PRAK 93 5
PRK2 78 1
ROCK 2 92 7
RSK1 94 4
RSK2 85 7
S6K1 98 1
SGK1 106 5
SmMLCK 86 7
Src 97 3
SRPK1 87 1
SYK 83 2
TBK1 103 11
YES1 86 4
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 87 6
ASK1 109 3
Aurora A 94 4
Aurora B 100 10
BRSK1 94 4
BRSK2 95 5
BTK 75 2
CAMK1 44 7
CAMKK beta 104 1
CDK2-Cyclin A 108 14
CHK1 98 10
CHK2 89 11
CK1 delta 94 0
CK2 111 0
CLK2 96 10
CSK 102 2
DAPK1 91 4
DYRK1A 84 2
DYRK2 88 5
DYRK3 91 11
EF2K 61 6
EPH-A2 103 6
EPH-A4 101 1
EPH-B1 100 8
EPH-B2 100 8
EPH-B3 96 14
EPH-B4 95 13
ERK1 92 8
ERK2 103 4
ERK8 87 4
FGF-R1 80 7
GCK 89 2
GSK3 beta 103 1
HER4 95 4
HIPK1 77 2
HIPK2 81 4
HIPK3 95 8
IGF-1R 96 0
IKK beta 93 8
IKK epsilon 76 3
IR 109 3
IRAK4 93 6
IRR 94 3
JAK2 103 2
JNK1 90 2
JNK2 92 11
JNK3 104 9
Lck 90 4
LKB1 89 0
MAPKAP-K2 91 3
MAPKAP-K3 88 2
MARK1 79 1
MARK2 93 3
MARK3 98 5
MARK4 103 3
MEKK1 98 2
MELK 79 2
MINK1 54 9
MKK1 84 12
MKK2 101 3
MKK6 101 11
MLK1 73 0
MLK3 89 4
MNK1 110 2
MNK2 100 2
MSK1 94 4
MST2 66 1
MST4 83 2
NEK2a 90 3
NEK6 117 8
NUAK1 71 0
p38 alpha MAPK 82 1
p38 beta MAPK 108 9
p38 delta MAPK 88 8
p38 gamma MAPK 97 3
PAK2 92 8
PAK4 68 9
PAK5 63 1
PAK6 109 8
PDK1 108 4
PHK 102 11
PIM1 80 0
PIM2 86 1
PIM3 63 1
PKA 100 10
PKB alpha 95 4
PKB beta 65 7
PKC alpha 82 3
PKC zeta 113 4
PKD1 86 7
PLK1 98 4
PRAK 92 5
PRK2 79 7
RIPK2 57 3
ROCK 2 82 10
RSK1 97 4
RSK2 74 1
S6K1 106 8
SGK1 98 4
SmMLCK 82 13
Src 105 9
SRPK1 84 7
SYK 89 7
TAK1 78 8
TAO1 87 4
TBK1 88 4
TrkA 76 7
TTK 92 3
VEGFR1 71 3
YES1 79 6
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 92 10
Aurora B 60 3
Aurora C 65 0
BRSK2 92 12
CAMK1
3
 0
CAMKK alpha 62 3
CAMKK beta 108 9
CDK2-Cyclin A 97 13
CHK1 85 2
CHK2 82 7
CK1 delta 110 2
CK2 91 14
CSK 103 15
DYRK1A 93 12
DYRK2 118 1
DYRK3 74 1
EF2K 40 6
EPH-A2 84 7
ERK1 99 5
ERK2 75 14
ERK8 70 1
FGF-R1 75 3
GSK3 beta 77 9
HIPK2 84 3
HIPK3 65 2
IKK beta 89 2
IKK epsilon 67 6
IRR 81 13
JNK1 70 9
JNK2 81 12
JNK3 80 7
Lck 64 6
MAPKAP-K2 59 1
MAPKAP-K3 71 5
MARK3 95 12
MELK 67 0
MKK1 76 10
MNK1 84 1
MNK2 79 3
MSK1 93 14
MST2 78 2
MST4 80 4
NEK2a 99 3
NEK6 75 3
NEK7 84 10
p38 alpha MAPK 98 13
p38 beta MAPK 113 3
p38 delta MAPK 98 11
p38 gamma MAPK 93 9
PAK4 48 4
PAK5 60 3
PAK6 92 1
PDK1 94 7
PHK 101 9
PIM1 56 6
PIM2 89 3
PIM3 59 6
PKA 76 5
PKB alpha 64 8
PKB beta 87 14
PKC alpha 87 8
PKC zeta 96 9
PKD1 82 14
PLK1 89 2
PRAK 79 5
PRK2 67 10
ROCK 2 91 1
RSK1 67 1
RSK2 74 1
S6K1 71 6
SGK1 82 3
SmMLCK 11 4
Src 118 1
SRPK1 84 9
SYK 84 10
TBK1 106 10
YES1 88 8
Screen Conc: 100.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 97 0
Aurora B 56 11
Aurora C 70 15
BRSK2 76 9
CAMK1
8
 0
CDK2-Cyclin A 93 3
CHK1 88 5
CHK2 58 3
CK1 delta 88 5
CK2 84 7
CSK 92 0
DYRK1A 99 5
DYRK2 106 0
DYRK3 60 4
EF2K 43 1
EPH-A2 69 1
ERK1 87 2
ERK2 45 1
ERK8 51 1
FGF-R1 55 0
GSK3 beta 43 9
HIPK2 61 1
HIPK3 68 2
IKK beta 98 2
IKK epsilon 100 1
IRR 68 1
JNK1 48 1
JNK2 80 7
JNK3 42 1
Lck 31 3
MAPKAP-K2 12 0
MAPKAP-K3 52 2
MARK3 90 8
MELK 45 5
MKK1 14 3
MNK1 82 0
MNK2 77 10
MSK1 41 1
MST2 83 7
MST4 92 6
NEK2a 70 2
NEK6 44 1
NEK7 15 0
p38 alpha MAPK 83 2
p38 beta MAPK 86 15
p38 delta MAPK 89 3
p38 gamma MAPK 87 0
PAK4 33 1
PAK5 63 5
PAK6 66 1
PDK1 98 15
PHK 59 2
PIM1 17 1
PIM2 23 0
PIM3 16 1
PKA 39 0
PKB alpha
6
 0
PKB beta 26 2
PKC alpha 96 3
PKC zeta 104 8
PKD1 81 3
PLK1 83 2
PRAK 51 4
PRK2 59 2
ROCK 2 92 9
RSK1 36 1
RSK2 22 1
S6K1 34 11
SGK1 14 5
SmMLCK
-1
 0
Src 62 5
SRPK1 67 0
SYK 44 2
TBK1 100 4
YES1 61 2