Inhibitor |
Akt Inhibitor IV
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
98
|
0
|
|
Aurora B
|
96
|
7
|
|
BRSK2
|
79
|
10
|
|
BTK
|
98
|
4
|
|
CAMK1
|
94
|
2
|
|
CAMKK beta
|
109
|
0
|
|
CDK2-Cyclin A
|
88
|
1
|
|
CHK1
|
89
|
4
|
|
CHK2
|
99
|
11
|
|
CK1 delta
|
98
|
2
|
|
CK2
|
104
|
12
|
|
CSK
|
94
|
11
|
|
DYRK1A
|
99
|
6
|
|
DYRK2
|
88
|
0
|
|
DYRK3
|
99
|
1
|
|
EF2K
|
123
|
13
|
|
EPH-A2
|
86
|
11
|
|
EPH-B3
|
74
|
3
|
|
ERK1
|
104
|
11
|
|
ERK2
|
93
|
5
|
|
ERK8
|
91
|
5
|
|
FGF-R1
|
90
|
14
|
|
GCK
|
80
|
1
|
|
GSK3 beta
|
102
|
7
|
|
HER4
|
70
|
1
|
|
HIPK2
|
101
|
1
|
|
IGF-1R
|
95
|
6
|
|
IKK beta
|
72
|
0
|
|
IKK epsilon
|
97
|
11
|
|
IR
|
93
|
10
|
|
IRAK4
|
83
|
2
|
|
IRR
|
102
|
1
|
|
JNK1
|
100
|
6
|
|
JNK2
|
95
|
6
|
|
Lck
|
74
|
0
|
|
LKB1
|
97
|
9
|
|
MAPKAP-K2
|
93
|
1
|
|
MARK3
|
99
|
10
|
|
MELK
|
109
|
2
|
|
MINK1
|
97
|
15
|
|
MKK1
|
68
|
0
|
|
MLK1
|
80
|
10
|
|
MLK3
|
126
|
3
|
|
MNK1
|
93
|
2
|
|
MNK2
|
89
|
3
|
|
MSK1
|
91
|
6
|
|
MST2
|
106
|
0
|
|
MST4
|
94
|
12
|
|
NEK2a
|
102
|
7
|
|
NEK6
|
92
|
6
|
|
NUAK1
|
139
|
11
|
|
p38 alpha MAPK
|
99
|
1
|
|
p38 beta MAPK
|
105
|
6
|
|
p38 delta MAPK
|
95
|
8
|
|
p38 gamma MAPK
|
99
|
6
|
|
PAK4
|
104
|
1
|
|
PAK5
|
109
|
1
|
|
PAK6
|
99
|
1
|
|
PDK1
|
128
|
0
|
|
PHK
|
90
|
0
|
|
PIM1
|
90
|
10
|
|
PIM2
|
99
|
1
|
|
PIM3
|
79
|
9
|
|
PKA
|
104
|
6
|
|
PKB alpha
|
99
|
16
|
|
PKB beta
|
93
|
1
|
|
PKC alpha
|
97
|
2
|
|
PKC zeta
|
99
|
4
|
|
PKD1
|
102
|
4
|
|
PLK1
|
107
|
3
|
|
PRAK
|
94
|
8
|
|
PRK2
|
99
|
1
|
|
ROCK 2
|
99
|
3
|
|
RSK1
|
80
|
4
|
|
RSK2
|
103
|
19
|
|
S6K1
|
83
|
4
|
|
SGK1
|
65
|
16
|
|
SmMLCK
|
89
|
5
|
|
Src
|
90
|
10
|
|
SRPK1
|
80
|
36
|
|
SYK
|
89
|
9
|
|
TBK1
|
91
|
8
|
|
TTK
|
109
|
10
|
|
VEGFR1
|
116
|
0
|
|
YES1
|
101
|
9
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
92
|
8
|
|
Aurora B
|
82
|
6
|
|
BRSK2
|
101
|
4
|
|
BTK
|
148
|
30
|
|
CAMK1
|
22
|
1
|
|
CAMKK beta
|
91
|
4
|
|
CDK2-Cyclin A
|
89
|
0
|
|
CHK1
|
70
|
6
|
|
CHK2
|
90
|
4
|
|
CK1 delta
|
108
|
10
|
|
CK2
|
95
|
3
|
|
CSK
|
74
|
2
|
|
DYRK1A
|
71
|
7
|
|
DYRK2
|
64
|
2
|
|
DYRK3
|
90
|
0
|
|
EF2K
|
130
|
1
|
|
EPH-A2
|
72
|
6
|
|
EPH-B3
|
79
|
0
|
|
ERK1
|
100
|
7
|
|
ERK2
|
96
|
1
|
|
ERK8
|
85
|
4
|
|
FGF-R1
|
91
|
2
|
|
GCK
|
64
|
0
|
|
GSK3 beta
|
95
|
5
|
|
HER4
|
104
|
5
|
|
HIPK2
|
80
|
1
|
|
IGF-1R
|
62
|
0
|
|
IKK beta
|
65
|
0
|
|
IKK epsilon
|
91
|
16
|
|
IR
|
88
|
18
|
|
IRAK4
|
64
|
0
|
|
IRR
|
88
|
2
|
|
JNK1
|
100
|
9
|
|
JNK2
|
91
|
3
|
|
Lck
|
45
|
3
|
|
LKB1
|
89
|
6
|
|
MAPKAP-K2
|
85
|
4
|
|
MARK3
|
89
|
1
|
|
MELK
|
63
|
9
|
|
MINK1
|
65
|
0
|
|
MKK1
|
42
|
0
|
|
MLK1
|
54
|
9
|
|
MLK3
|
88
|
1
|
|
MNK1
|
99
|
8
|
|
MNK2
|
75
|
2
|
|
MSK1
|
61
|
6
|
|
MST2
|
88
|
5
|
|
MST4
|
68
|
7
|
|
NEK2a
|
63
|
12
|
|
NEK6
|
52
|
14
|
|
NUAK1
|
111
|
4
|
|
p38 alpha MAPK
|
88
|
6
|
|
p38 beta MAPK
|
100
|
4
|
|
p38 delta MAPK
|
95
|
11
|
|
p38 gamma MAPK
|
80
|
1
|
|
PAK4
|
94
|
11
|
|
PAK5
|
116
|
4
|
|
PAK6
|
113
|
3
|
|
PDK1
|
126
|
3
|
|
PHK
|
74
|
5
|
|
PIM1
|
64
|
0
|
|
PIM2
|
90
|
12
|
|
PIM3
|
50
|
0
|
|
PKA
|
91
|
4
|
|
PKB alpha
|
53
|
24
|
|
PKB beta
|
79
|
2
|
|
PKC alpha
|
75
|
0
|
|
PKC zeta
|
78
|
2
|
|
PKD1
|
50
|
12
|
|
PLK1
|
144
|
2
|
|
PRAK
|
96
|
20
|
|
PRK2
|
76
|
7
|
|
ROCK 2
|
77
|
9
|
|
RSK1
|
47
|
4
|
|
RSK2
|
99
|
7
|
|
S6K1
|
44
|
9
|
|
SGK1
|
40
|
10
|
|
SmMLCK
|
56
|
3
|
|
Src
|
103
|
8
|
|
SRPK1
|
78
|
33
|
|
SYK
|
59
|
16
|
|
TBK1
|
76
|
2
|
|
TTK
|
92
|
1
|
|
VEGFR1
|
126
|
15
|
|
YES1
|
112
|
6
|
