Inhibitor | Akt Inhibitor IV
Screening Results Tables
Screen Conc: 1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
| AMPK |
98
|
0 |
| Aurora B |
96
|
7 |
| BRSK2 |
79
|
10 |
| BTK |
98
|
4 |
| CAMK1 |
94
|
2 |
| CAMKK beta |
109
|
0 |
| CDK2-Cyclin A |
88
|
1 |
| CHK1 |
89
|
4 |
| CHK2 |
99
|
11 |
| CK1 delta |
98
|
2 |
| CK2 |
104
|
12 |
| CSK |
94
|
11 |
| DYRK1A |
99
|
6 |
| DYRK2 |
88
|
0 |
| DYRK3 |
99
|
1 |
| EF2K |
123
|
13 |
| EPH-A2 |
86
|
11 |
| EPH-B3 |
74
|
3 |
| ERK1 |
104
|
11 |
| ERK2 |
93
|
5 |
| ERK8 |
91
|
5 |
| FGF-R1 |
90
|
14 |
| GCK |
80
|
1 |
| GSK3 beta |
102
|
7 |
| HER4 |
70
|
1 |
| HIPK2 |
101
|
1 |
| IGF-1R |
95
|
6 |
| IKK beta |
72
|
0 |
| IKK epsilon |
97
|
11 |
| IR |
93
|
10 |
| IRAK4 |
83
|
2 |
| IRR |
102
|
1 |
| JNK1 |
100
|
6 |
| JNK2 |
95
|
6 |
| Lck |
74
|
0 |
| LKB1 |
97
|
9 |
| MAPKAP-K2 |
93
|
1 |
| MARK3 |
99
|
10 |
| MELK |
109
|
2 |
| MINK1 |
97
|
15 |
| MKK1 |
68
|
0 |
| MLK1 |
80
|
10 |
| MLK3 |
126
|
3 |
| MNK1 |
93
|
2 |
| MNK2 |
89
|
3 |
| MSK1 |
91
|
6 |
| MST2 |
106
|
0 |
| MST4 |
94
|
12 |
| NEK2a |
102
|
7 |
| NEK6 |
92
|
6 |
| NUAK1 |
139
|
11 |
| p38 alpha MAPK |
99
|
1 |
| p38 beta MAPK |
105
|
6 |
| p38 delta MAPK |
95
|
8 |
| p38 gamma MAPK |
99
|
6 |
| PAK4 |
104
|
1 |
| PAK5 |
109
|
1 |
| PAK6 |
99
|
1 |
| PDK1 |
128
|
0 |
| PHK |
90
|
0 |
| PIM1 |
90
|
10 |
| PIM2 |
99
|
1 |
| PIM3 |
79
|
9 |
| PKA |
104
|
6 |
| PKB alpha |
99
|
16 |
| PKB beta |
93
|
1 |
| PKC alpha |
97
|
2 |
| PKC zeta |
99
|
4 |
| PKD1 |
102
|
4 |
| PLK1 |
107
|
3 |
| PRAK |
94
|
8 |
| PRK2 |
99
|
1 |
| ROCK 2 |
99
|
3 |
| RSK1 |
80
|
4 |
| RSK2 |
103
|
19 |
| S6K1 |
83
|
4 |
| SGK1 |
65
|
16 |
| SmMLCK |
89
|
5 |
| Src |
90
|
10 |
| SRPK1 |
80
|
36 |
| SYK |
89
|
9 |
| TBK1 |
91
|
8 |
| TTK |
109
|
10 |
| VEGFR1 |
116
|
0 |
| YES1 |
101
|
9 |
Screen Conc: 10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
| AMPK |
92
|
8 |
| Aurora B |
82
|
6 |
| BRSK2 |
101
|
4 |
| BTK |
148
|
30 |
| CAMK1 |
22
|
1 |
| CAMKK beta |
91
|
4 |
| CDK2-Cyclin A |
89
|
0 |
| CHK1 |
70
|
6 |
| CHK2 |
90
|
4 |
| CK1 delta |
108
|
10 |
| CK2 |
95
|
3 |
| CSK |
74
|
2 |
| DYRK1A |
71
|
7 |
| DYRK2 |
64
|
2 |
| DYRK3 |
90
|
0 |
| EF2K |
130
|
1 |
| EPH-A2 |
72
|
6 |
| EPH-B3 |
79
|
0 |
| ERK1 |
100
|
7 |
| ERK2 |
96
|
1 |
| ERK8 |
85
|
4 |
| FGF-R1 |
91
|
2 |
| GCK |
64
|
0 |
| GSK3 beta |
95
|
5 |
| HER4 |
104
|
5 |
| HIPK2 |
80
|
1 |
| IGF-1R |
62
|
0 |
| IKK beta |
65
|
0 |
| IKK epsilon |
91
|
16 |
| IR |
88
|
18 |
| IRAK4 |
64
|
0 |
| IRR |
88
|
2 |
| JNK1 |
100
|
9 |
| JNK2 |
91
|
3 |
| Lck |
45
|
3 |
| LKB1 |
89
|
6 |
| MAPKAP-K2 |
85
|
4 |
| MARK3 |
89
|
1 |
| MELK |
63
|
9 |
| MINK1 |
65
|
0 |
| MKK1 |
42
|
0 |
| MLK1 |
54
|
9 |
| MLK3 |
88
|
1 |
| MNK1 |
99
|
8 |
| MNK2 |
75
|
2 |
| MSK1 |
61
|
6 |
| MST2 |
88
|
5 |
| MST4 |
68
|
7 |
| NEK2a |
63
|
12 |
| NEK6 |
52
|
14 |
| NUAK1 |
111
|
4 |
| p38 alpha MAPK |
88
|
6 |
| p38 beta MAPK |
100
|
4 |
| p38 delta MAPK |
95
|
11 |
| p38 gamma MAPK |
80
|
1 |
| PAK4 |
94
|
11 |
| PAK5 |
116
|
4 |
| PAK6 |
113
|
3 |
| PDK1 |
126
|
3 |
| PHK |
74
|
5 |
| PIM1 |
64
|
0 |
| PIM2 |
90
|
12 |
| PIM3 |
50
|
0 |
| PKA |
91
|
4 |
| PKB alpha |
53
|
24 |
| PKB beta |
79
|
2 |
| PKC alpha |
75
|
0 |
| PKC zeta |
78
|
2 |
| PKD1 |
50
|
12 |
| PLK1 |
144
|
2 |
| PRAK |
96
|
20 |
| PRK2 |
76
|
7 |
| ROCK 2 |
77
|
9 |
| RSK1 |
47
|
4 |
| RSK2 |
99
|
7 |
| S6K1 |
44
|
9 |
| SGK1 |
40
|
10 |
| SmMLCK |
56
|
3 |
| Src |
103
|
8 |
| SRPK1 |
78
|
33 |
| SYK |
59
|
16 |
| TBK1 |
76
|
2 |
| TTK |
92
|
1 |
| VEGFR1 |
126
|
15 |
| YES1 |
112
|
6 |
