Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


 1.00 87
PCI-32765 (Ibrutinib)   C25H24N6O2 440.50 Btk Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080


 0.10 97
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 1.00 29
SGK1-Sanofi-ex.290-R   C24H25ClN6O5S 545.01 SGK1
WO2014140065
 1.00 95
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 64
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 10.00 118
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 99
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 81
2-Aminopurine   C5H5N5 135.13 PKR

100.00 108
A-769662   C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

US7119205
 10.00 110