Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


1.00 66
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 75
SYK Inhibitor III   C9H7NO4 193.20 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380


 10.00 66
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 10.00 94
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 10.00 104
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105

WO1998027098
 10.00 96
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 91
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 46
2-Aminopurine   C5H5N5 135.13 PKR

100.00 84
A-769662   C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

US7119205
 10.00 93