Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…
MLN120B   C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273 Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705
MLN4924   C21H26ClN5O4S 479.98 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736
MLN9708   C20H23BCl2N2O9 517.12 Proteasome Kupperman. E. (2010) Cancer Research 70 1970-1980
Mobocertinib   C32H39N7O4 585.70 EGFR
MRT199665   C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91
MRT67307   C26H36N6O2 464.60 IKKε, TBK1 Clark K. (2011) Biochem. J. 434 93-104
MSC 2032964A   C16H13F3N6O 362.31 ASK1 Guo X. (2010) EMBO Molecular Medicine 2 504-515
Necitumumab   EGFR
Necrostatin-1 (Nec-1)   C13H13N3OS 259.33 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321
Nectrostatin-1 (Nec-1 inactive analog)   C12H11N3OS 245.30 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321
Neratinib   C30H29ClN6O3 557.00 EGFR
Netarsudil   C28H27N3O3 ROCK
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371 Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228
NIK SMI1 (+) dextrorotatory   C20H19N3O4 365.39 NIK inhibitor
NIK SMI1 (-) levorotatory   C20H19N3O4 365.39 NIK inhibitor
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
Nilotinib   C28H22F3N7O Bcr-Ab1
Nimotuzumab EGFR
Nintedanib   C31H33N5O4 539.60 VEGFR; PDGFR; FGFR