Inhibitor | MLN4924  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
MLN4924   C21H26ClN5O4S 479.98 905579-51-3 16720766 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 96 19
ASK1 87 8
Aurora A 103 3
Aurora B 88 24
BRSK1 89 13
BRSK2 92 11
BTK 106 27
CAMK1 114 3
CAMKK beta 96 10
CDK2-Cyclin A 84 3
CHK1 91 13
CHK2 71 24
CK1 delta 86 5
CK2 80 8
CLK2 127 3
CSK 78 14
DAPK1 110 12
DYRK1A 96 14
DYRK2 93 17
DYRK3 87 29
EF2K 100 15
EPH-A2 113 20
EPH-A4 92 21
EPH-B1 102 28
EPH-B2 107 3
EPH-B3 132 35
EPH-B4 106 4
ERK1 77 12
ERK2 106 28
ERK8 104 21
FGF-R1 138 22
GCK 91 13
GSK3 beta 93 9
HER4 110 5
HIPK1 98 14
HIPK2 88 0
HIPK3 84 16
IGF-1R 94 6
IKK beta 100 3
IKK epsilon 73 14
IR 89 8
IRAK4 96 22
IRR 87 18
JAK2 89 11
JNK1 84 13
JNK2 83 16
JNK3 81 10
Lck 98 10
LKB1 127 13
MAPKAP-K2 88 10
MAPKAP-K3 103 13
MARK1 100 3
MARK2 90 9
MARK3 101 11
MARK4 93 15
MEKK1 101 26
MELK 87 16
MINK1 93 13
MKK1 95 13
MKK2 104 6
MKK6 95 0
MLK1 82 3
MLK3 92 1
MNK1 104 7
MNK2 114 23
MSK1 103 9
MST2 87 2
MST4 83 19
NEK2a 109 4
NEK6 95 26
NUAK1 98 9
p38 alpha MAPK 100 24
p38 beta MAPK 95 14
p38 delta MAPK 92 11
p38 gamma MAPK 101 19
PAK2 98 14
PAK4 101 11
PAK5 89 20
PAK6 94 17
PDK1 94 11
PHK 109 8
PIM1 87 20
PIM2 94 20
PIM3 88 41
PKA 73 14
PKB alpha 118 2
PKB beta 93 22
PKC alpha 88 20
PKC zeta 115 27
PKD1 90 17
PLK1 93 7
PRAK 89 22
PRK2 90 1
RIPK2 107 13
ROCK 2 97 24
RSK1 96 2
RSK2 100 3
S6K1 94 16
SGK1 95 11
SmMLCK 91 34
Src 125 27
SRPK1 92 15
SYK 92 18
TAK1 107 3
TAO1 104 7
TBK1 97 22
TrkA 99 39
TTK 86 1
VEGFR1 89 11
YES1 93 43
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 99 7
ASK1 87 7
Aurora A 97 5
Aurora B 93 7
BRSK1 129 54
BRSK2 86 13
BTK 105 6
CAMK1 110 5
CAMKK beta 108 6
CDK2-Cyclin A 90 6
CHK1 98 6
CHK2 67 4
CK1 delta 84 1
CK2 88 11
CLK2 119 22
CSK 103 24
DAPK1 113 15
DYRK1A 103 1
DYRK2 92 16
DYRK3 84 10
EF2K 107 9
EPH-A2 105 18
EPH-A4 105 3
EPH-B1 100 11
EPH-B2 109 6
EPH-B3 129 10
EPH-B4 108 5
ERK1 73 4
ERK2 89 7
ERK8 104 20
FGF-R1 126 1
GCK 88 5
GSK3 beta 98 8
HER4 116 4
HIPK1 98 29
HIPK2 97 10
HIPK3 89 6
IGF-1R 88 11
IKK beta 96 1
IKK epsilon 78 2
IR 93 5
IRAK4 99 4
IRR 83 8
JAK2 93 10
JNK1 97 1
JNK2 88 2
JNK3 82 10
Lck 110 8
LKB1 104 3
MAPKAP-K2 93 3
MAPKAP-K3 101 8
MARK1 107 8
MARK2 88 1
MARK3 100 15
MARK4 103 0
MEKK1 107 5
MELK 91 6
MINK1 96 7
MKK1 99 7
MKK2 99 2
MKK6 94 10
MLK1 88 1
MLK3 92 12
MNK1 92 11
MNK2 108 4
MSK1 110 14
MST2 84 8
MST4 88 10
NEK2a 100 5
NEK6 102 12
NUAK1 96 4
p38 alpha MAPK 102 16
p38 beta MAPK 98 14
p38 delta MAPK 90 4
p38 gamma MAPK 95 5
PAK2 93 4
PAK4 106 8
PAK5 89 10
PAK6 91 16
PDK1 94 7
PHK 106 10
PIM1 103 18
PIM2 101 5
PIM3 78 14
PKA 81 8
PKB alpha 119 15
PKB beta 88 5
PKC alpha 88 3
PKC zeta 96 16
PKD1 97 6
PLK1 95 5
PRAK 99 30
PRK2 92 13
RIPK2 121 5
ROCK 2 81 12
RSK1 95 12
RSK2 96 2
S6K1 85 12
SGK1 112 7
SmMLCK 118 21
Src 113 15
SRPK1 102 7
SYK 104 6
TAK1 105 8
TAO1 100 12
TBK1 88 4
TrkA 92 1
TTK 98 1
VEGFR1 104 5
YES1 79 3