Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
MLN4924 | C21H26ClN5O4S | 479.98 | 905579-51-3 | 16720766 | NEDD8-activating enzyme | Teresa A. Soucy (2009) Nature 458 732-736 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 96 | 19 |
ASK1 | 87 | 8 |
Aurora A | 103 | 3 |
Aurora B | 88 | 24 |
BRSK1 | 89 | 13 |
BRSK2 | 92 | 11 |
BTK | 106 | 27 |
CAMK1 | 114 | 3 |
CAMKK beta | 96 | 10 |
CDK2-Cyclin A | 84 | 3 |
CHK1 | 91 | 13 |
CHK2 | 71 | 24 |
CK1 delta | 86 | 5 |
CK2 | 80 | 8 |
CLK2 | 127 | 3 |
CSK | 78 | 14 |
DAPK1 | 110 | 12 |
DYRK1A | 96 | 14 |
DYRK2 | 93 | 17 |
DYRK3 | 87 | 29 |
EF2K | 100 | 15 |
EPH-A2 | 113 | 20 |
EPH-A4 | 92 | 21 |
EPH-B1 | 102 | 28 |
EPH-B2 | 107 | 3 |
EPH-B3 | 132 | 35 |
EPH-B4 | 106 | 4 |
ERK1 | 77 | 12 |
ERK2 | 106 | 28 |
ERK8 | 104 | 21 |
FGF-R1 | 138 | 22 |
GCK | 91 | 13 |
GSK3 beta | 93 | 9 |
HER4 | 110 | 5 |
HIPK1 | 98 | 14 |
HIPK2 | 88 | 0 |
HIPK3 | 84 | 16 |
IGF-1R | 94 | 6 |
IKK beta | 100 | 3 |
IKK epsilon | 73 | 14 |
IR | 89 | 8 |
IRAK4 | 96 | 22 |
IRR | 87 | 18 |
JAK2 | 89 | 11 |
JNK1 | 84 | 13 |
JNK2 | 83 | 16 |
JNK3 | 81 | 10 |
Lck | 98 | 10 |
LKB1 | 127 | 13 |
MAPKAP-K2 | 88 | 10 |
MAPKAP-K3 | 103 | 13 |
MARK1 | 100 | 3 |
MARK2 | 90 | 9 |
MARK3 | 101 | 11 |
MARK4 | 93 | 15 |
MEKK1 | 101 | 26 |
MELK | 87 | 16 |
MINK1 | 93 | 13 |
MKK1 | 95 | 13 |
MKK2 | 104 | 6 |
MKK6 | 95 | 0 |
MLK1 | 82 | 3 |
MLK3 | 92 | 1 |
MNK1 | 104 | 7 |
MNK2 | 114 | 23 |
MSK1 | 103 | 9 |
MST2 | 87 | 2 |
MST4 | 83 | 19 |
NEK2a | 109 | 4 |
NEK6 | 95 | 26 |
NUAK1 | 98 | 9 |
p38 alpha MAPK | 100 | 24 |
p38 beta MAPK | 95 | 14 |
p38 delta MAPK | 92 | 11 |
p38 gamma MAPK | 101 | 19 |
PAK2 | 98 | 14 |
PAK4 | 101 | 11 |
PAK5 | 89 | 20 |
PAK6 | 94 | 17 |
PDK1 | 94 | 11 |
PHK | 109 | 8 |
PIM1 | 87 | 20 |
PIM2 | 94 | 20 |
PIM3 | 88 | 41 |
PKA | 73 | 14 |
PKB alpha | 118 | 2 |
PKB beta | 93 | 22 |
PKC alpha | 88 | 20 |
PKC zeta | 115 | 27 |
PKD1 | 90 | 17 |
PLK1 | 93 | 7 |
PRAK | 89 | 22 |
PRK2 | 90 | 1 |
RIPK2 | 107 | 13 |
ROCK 2 | 97 | 24 |
RSK1 | 96 | 2 |
RSK2 | 100 | 3 |
S6K1 | 94 | 16 |
SGK1 | 95 | 11 |
SmMLCK | 91 | 34 |
Src | 125 | 27 |
SRPK1 | 92 | 15 |
SYK | 92 | 18 |
TAK1 | 107 | 3 |
TAO1 | 104 | 7 |
TBK1 | 97 | 22 |
TrkA | 99 | 39 |
TTK | 86 | 1 |
VEGFR1 | 89 | 11 |
YES1 | 93 | 43 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 99 | 7 |
ASK1 | 87 | 7 |
Aurora A | 97 | 5 |
Aurora B | 93 | 7 |
BRSK1 | 129 | 54 |
BRSK2 | 86 | 13 |
BTK | 105 | 6 |
CAMK1 | 110 | 5 |
CAMKK beta | 108 | 6 |
CDK2-Cyclin A | 90 | 6 |
CHK1 | 98 | 6 |
CHK2 | 67 | 4 |
CK1 delta | 84 | 1 |
CK2 | 88 | 11 |
CLK2 | 119 | 22 |
CSK | 103 | 24 |
DAPK1 | 113 | 15 |
DYRK1A | 103 | 1 |
DYRK2 | 92 | 16 |
DYRK3 | 84 | 10 |
EF2K | 107 | 9 |
EPH-A2 | 105 | 18 |
EPH-A4 | 105 | 3 |
EPH-B1 | 100 | 11 |
EPH-B2 | 109 | 6 |
EPH-B3 | 129 | 10 |
EPH-B4 | 108 | 5 |
ERK1 | 73 | 4 |
ERK2 | 89 | 7 |
ERK8 | 104 | 20 |
FGF-R1 | 126 | 1 |
GCK | 88 | 5 |
GSK3 beta | 98 | 8 |
HER4 | 116 | 4 |
HIPK1 | 98 | 29 |
HIPK2 | 97 | 10 |
HIPK3 | 89 | 6 |
IGF-1R | 88 | 11 |
IKK beta | 96 | 1 |
IKK epsilon | 78 | 2 |
IR | 93 | 5 |
IRAK4 | 99 | 4 |
IRR | 83 | 8 |
JAK2 | 93 | 10 |
JNK1 | 97 | 1 |
JNK2 | 88 | 2 |
JNK3 | 82 | 10 |
Lck | 110 | 8 |
LKB1 | 104 | 3 |
MAPKAP-K2 | 93 | 3 |
MAPKAP-K3 | 101 | 8 |
MARK1 | 107 | 8 |
MARK2 | 88 | 1 |
MARK3 | 100 | 15 |
MARK4 | 103 | 0 |
MEKK1 | 107 | 5 |
MELK | 91 | 6 |
MINK1 | 96 | 7 |
MKK1 | 99 | 7 |
MKK2 | 99 | 2 |
MKK6 | 94 | 10 |
MLK1 | 88 | 1 |
MLK3 | 92 | 12 |
MNK1 | 92 | 11 |
MNK2 | 108 | 4 |
MSK1 | 110 | 14 |
MST2 | 84 | 8 |
MST4 | 88 | 10 |
NEK2a | 100 | 5 |
NEK6 | 102 | 12 |
NUAK1 | 96 | 4 |
p38 alpha MAPK | 102 | 16 |
p38 beta MAPK | 98 | 14 |
p38 delta MAPK | 90 | 4 |
p38 gamma MAPK | 95 | 5 |
PAK2 | 93 | 4 |
PAK4 | 106 | 8 |
PAK5 | 89 | 10 |
PAK6 | 91 | 16 |
PDK1 | 94 | 7 |
PHK | 106 | 10 |
PIM1 | 103 | 18 |
PIM2 | 101 | 5 |
PIM3 | 78 | 14 |
PKA | 81 | 8 |
PKB alpha | 119 | 15 |
PKB beta | 88 | 5 |
PKC alpha | 88 | 3 |
PKC zeta | 96 | 16 |
PKD1 | 97 | 6 |
PLK1 | 95 | 5 |
PRAK | 99 | 30 |
PRK2 | 92 | 13 |
RIPK2 | 121 | 5 |
ROCK 2 | 81 | 12 |
RSK1 | 95 | 12 |
RSK2 | 96 | 2 |
S6K1 | 85 | 12 |
SGK1 | 112 | 7 |
SmMLCK | 118 | 21 |
Src | 113 | 15 |
SRPK1 | 102 | 7 |
SYK | 104 | 6 |
TAK1 | 105 | 8 |
TAO1 | 100 | 12 |
TBK1 | 88 | 4 |
TrkA | 92 | 1 |
TTK | 98 | 1 |
VEGFR1 | 104 | 5 |
YES1 | 79 | 3 |