Inhibitor | MRT199665  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
MRT199665   C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 78 7
AMPK
7
 0
AMPK (hum)
5
 0
ASK1 90 18
Aurora A 66 9
Aurora B 35 1
BRK 103 9
BRSK1 107 15
BRSK2 103 3
BTK 44 2
CAMK1 79 6
CAMKK beta 35 1
CDK2-Cyclin A 58 0
CDK9-Cyclin T1 78 4
CHK1 69 2
CHK2 89 16
CK1 delta 109 4
CK1 gamma 2 80 2
CK2 93 4
CLK2 25 1
CSK 75 5
DAPK1 89 2
DDR2
8
 0
DYRK1A 91 8
DYRK2 97 13
DYRK3 90 5
EF2K 66 11
EIF2AK3 85 5
EPH-A2 27 8
EPH-A4 26 5
EPH-B1 34 3
EPH-B2 94 8
EPH-B3 100 8
EPH-B4 71 1
ERK1 100 1
ERK2 79 8
ERK5 87 4
ERK8 46 3
FGF-R1 19 4
GCK 87 8
GSK3 beta 88 7
HER4 94 4
HIPK1 95 17
HIPK2 67 7
HIPK3 103 6
IGF-1R 12 0
IKK beta 71 10
IKK epsilon 67 15
IR
8
 3
IRAK1 79 4
IRAK4 101 6
IRR 80 2
JAK2 22 5
JNK1 98 7
JNK2 89 9
JNK3 100 21
Lck
10
 3
LKB1 99 6
MAP4K3 89 14
MAP4K5 77 9
MAPKAP-K2 92 4
MAPKAP-K3 92 9
MARK1 25 7
MARK2 12 3
MARK3
2
 0
MARK4
3
 0
MEKK1 108 3
MELK
8
 1
MINK1 94 2
MKK1 120 10
MKK2 94 3
MKK6 95 2
MLK1
5
 0
MLK3
8
 2
MNK1 103 10
MNK2 89 2
MPSK1 95 3
MSK1 81 10
MST2 46 4
MST3 57 7
MST4 46 4
NEK2a 92 12
NEK6 91 12
NUAK1
3
 2
OSR1 75 0
p38 alpha MAPK 100 6
p38 beta MAPK 95 4
p38 delta MAPK 76 5
p38 gamma MAPK 100 3
PAK2 96 8
PAK4 76 1
PAK5 77 0
PAK6 96 7
PDGFRA 53 4
PDK1 61 11
PHK 40 11
PIM1 105 3
PIM2 103 0
PIM3 116 11
PKA 92 7
PKB alpha 81 3
PKB beta 87 1
PKC alpha 100 17
PKC gamma 102 1
PKC zeta 87 8
PKD1 16 1
PLK1 79 9
PRAK 83 2
PRK2 70 4
RIPK2 96 17
ROCK 2 92 7
RSK1 60 1
RSK2 61 0
S6K1 104 8
SGK1 80 10
SIK2
8
 2
SIK3 19 2
SmMLCK 91 5
Src 23 0
SRPK1 103 11
STK33 35 5
SYK 95 8
TAK1 43 12
TAO1 79 9
TBK1 85 8
TESK1 97 10
TGFBR1 119 10
TIE2 59 8
TLK1 99 1
TrkA 33 1
TSSK1 76 21
TTBK1 98 2
TTBK2 104 11
TTK 56 4
ULK1 52 6
ULK2 20 0
VEGFR1 25 2
WNK1 96 3
YES1 36 3
ZAP70 98 5
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 34 0
AMPK
1
 0
AMPK (hum)
2
 0
ASK1 85 11
Aurora A 14 2
Aurora B
7
 0
BRK 84 12
BRSK1 88 11
BRSK2 87 15
BTK 14 2
CAMK1 61 13
CAMKK beta 15 3
CDK2-Cyclin A 21 3
CDK9-Cyclin T1 34 13
CHK1 25 4
CHK2 56 13
CK1 delta 76 15
CK1 gamma 2 84 15
CK2 69 3
CLK2
4
 0
CSK
6
 3
DAPK1 73 4
DDR2
1
 0
DYRK1A 49 13
DYRK2 95 5
DYRK3 95 1
EF2K 72 16
EIF2AK3 90 9
EPH-A2
5
 2
EPH-A4
7
 2
EPH-B1
5
 1
EPH-B2 18 3
EPH-B3 82 10
EPH-B4 11 1
ERK1 78 1
ERK2 39 2
ERK5 64 4
ERK8 19 0
FGF-R1
2
 0
GCK 61 14
GSK3 beta 60 5
HER4 98 2
HIPK1 81 15
HIPK2 59 2
HIPK3 98 0
IGF-1R
3
 1
IKK beta 80 2
IKK epsilon 23 3
IR
5
 2
IRAK1 89 7
IRAK4 47 3
IRR 50 1
JAK2
5
 1
JNK1 85 0
JNK2 56 7
JNK3 67 9
Lck
7
 5
LKB1 88 3
MAP4K3 23 3
MAP4K5 40 13
MAPKAP-K2 85 22
MAPKAP-K3 89 20
MARK1 21 10
MARK2
8
 2
MARK3
1
 0
MARK4
1
 0
MEKK1 107 9
MELK
5
 3
MINK1 73 0
MKK1 117 43
MKK2 127 31
MKK6 83 3
MLK1
6
 1
MLK3
7
 1
MNK1 99 5
MNK2 86 6
MPSK1 94 1
MSK1 41 10
MST2 13 2
MST3 18 0
MST4 11 1
NEK2a 84 5
NEK6 86 10
NUAK1
2
 0
OSR1 32 3
p38 alpha MAPK 89 18
p38 beta MAPK 77 13
p38 delta MAPK 77 2
p38 gamma MAPK 101 2
PAK2 51 0
PAK4 40 0
PAK5 31 0
PAK6 55 1
PDGFRA 28 9
PDK1 21 2
PHK 15 4
PIM1 99 12
PIM2 104 2
PIM3 109 14
PKA 62 15
PKB alpha 95 5
PKB beta 81 1
PKC alpha 85 5
PKC gamma 101 3
PKC zeta 72 10
PKD1
8
 3
PLK1 82 9
PRAK 80 0
PRK2 35 3
RIPK2 88 31
ROCK 2 60 3
RSK1 15 0
RSK2 22 1
S6K1 77 15
SGK1 51 2
SIK2
3
 0
SIK3
5
 0
SmMLCK 68 8
Src
5
 1
SRPK1 93 0
STK33 12 1
SYK 57 7
TAK1
7
 1
TAO1 43 3
TBK1 64 15
TESK1 84 8
TGFBR1 122 28
TIE2 12 2
TLK1 102 5
TrkA
8
 2
TSSK1 17 2
TTBK1 100 18
TTBK2 97 5
TTK 40 2
ULK1 20 1
ULK2
5
 3
VEGFR1
9
 0
WNK1 87 8
YES1
8
 3
ZAP70 98 3