Inhibitor | MRT67307  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	92	5
AMPK	64	1
ASK1	105	3
Aurora A	87	4
Aurora B	80	11
BRK	96	2
BRSK1	99	3
BRSK2	88	1
BTK	89	3
CAMK1	104	13
CAMKK beta	58	3
CDK2-Cyclin A	86	10
CHK1	93	10
CHK2	105	7
CK1 delta	99	8
CK2	86	12
CLK2	63	3
CSK	98	13
DAPK1	84	4
DYRK1A	99	2
DYRK2	92	14
DYRK3	91	16
EF2K	98	4
EIF2AK3	92	1
EPH-A2	95	1
EPH-A4	103	1
EPH-B1	107	4
EPH-B2	88	13
EPH-B3	110	13
EPH-B4	101	11
ERK1	105	12
ERK2	111	5
ERK8	81	9
FGF-R1	83	12
GCK	77	6
GSK3 beta	95	15
HER4	90	3
HIPK1	96	11
HIPK2	95	7
HIPK3	91	6
IGF-1R	90	7
IKK beta	115	2
IKK epsilon	34	13
IR	97	9
IRAK1	96	14
IRAK4	95	5
IRR	107	1
JAK2	41	2
JNK1	93	4
JNK2	97	14
JNK3	110	4
Lck	80	1
LKB1	109	4
MAPKAP-K2	106	5
MAPKAP-K3	80	7
MARK1	16	4
MARK2	27	4
MARK3	15	12
MARK4	33	2
MEKK1	115	6
MELK	43	10
MINK1	123	15
MKK1	92	13
MKK2	106	0
MKK6	105	1
MLK1	40	9
MLK3	54	1
MNK1	89	2
MNK2	80	14
MPSK1	117	24
MSK1	98	3
MST2	110	2
MST4	87	4
NEK2a	107	11
NEK6	94	1
NUAK1	47	4
OSR1	83	8
p38 alpha MAPK	100	6
p38 beta MAPK	103	4
p38 delta MAPK	88	6
p38 gamma MAPK	88	5
PAK2	101	12
PAK4	100	1
PAK5	95	0
PAK6	87	14
PDK1	75	4
PHK	78	3
PIM1	114	14
PIM2	94	5
PIM3	104	8
PKA	90	4
PKB alpha	90	3
PKB beta	99	3
PKC alpha	79	0
PKC gamma	88	14
PKC zeta	90	1
PKD1	82	3
PLK1	89	1
PRAK	104	9
PRK2	87	1
RIPK2	109	7
ROCK 2	91	11
RSK1	73	1
RSK2	71	19
S6K1	101	11
SGK1	81	1
SmMLCK	87	8
Src	88	0
SRPK1	86	7
STK33	80	11
SYK	109	2
TAK1	96	7
TAO1	78	7
TBK1	12	1
TIE2	95	9
TLK1	90	8
TrkA	84	5
TTK	94	11
VEGFR1	87	9
YES1	113	9
ZAP70	92	3

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	97	6
AMPK	27	3
ASK1	88	1
Aurora A	29	1
Aurora B	54	5
BRK	110	2
BRSK1	82	5
BRSK2	75	5
BTK	77	3
CAMK1	101	13
CAMKK beta	21	0
CDK2-Cyclin A	47	5
CHK1	57	3
CHK2	72	0
CK1 delta	66	11
CK2	86	9
CLK2	21	2
CSK	112	1
DAPK1	72	7
DYRK1A	106	1
DYRK2	101	10
DYRK3	101	7
EF2K	110	2
EIF2AK3	86	11
EPH-A2	98	5
EPH-A4	114	11
EPH-B1	108	11
EPH-B2	78	17
EPH-B3	101	10
EPH-B4	117	7
ERK1	112	11
ERK2	110	4
ERK8	34	2
FGF-R1	63	5
GCK	64	2
GSK3 beta	96	7
HER4	95	1
HIPK1	94	11
HIPK2	95	15
HIPK3	108	3
IGF-1R	105	10
IKK beta	122	6
IKK epsilon	23	10
IR	100	15
IRAK1	79	4
IRAK4	83	5
IRR	118	7
JAK2	14	2
JNK1	115	6
JNK2	106	8
JNK3	97	11
Lck	67	2
LKB1	118	15
MAPKAP-K2	114	9
MAPKAP-K3	104	10
MARK1	9	2
MARK2	10	1
MARK3	1	1
MARK4	29	5
MEKK1	137	2
MELK	26	3
MINK1	103	7
MKK1	84	1
MKK2	75	10
MKK6	113	3
MLK1	16	3
MLK3	8	0
MNK1	96	3
MNK2	50	15
MPSK1	104	10
MSK1	68	2
MST2	129	1
MST4	94	9
NEK2a	97	11
NEK6	90	9
NUAK1	11	1
OSR1	94	5
p38 alpha MAPK	107	0
p38 beta MAPK	114	5
p38 delta MAPK	90	2
p38 gamma MAPK	85	8
PAK2	92	2
PAK4	79	2
PAK5	88	1
PAK6	84	4
PDK1	42	2
PHK	28	2
PIM1	120	12
PIM2	85	1
PIM3	111	2
PKA	100	12
PKB alpha	93	7
PKB beta	108	1
PKC alpha	93	7
PKC gamma	98	1
PKC zeta	95	10
PKD1	49	0
PLK1	98	10
PRAK	122	13
PRK2	66	6
RIPK2	112	8
ROCK 2	81	1
RSK1	34	2
RSK2	56	2
S6K1	101	1
SGK1	94	6
SmMLCK	103	3
Src	70	2
SRPK1	101	10
STK33	52	9
SYK	93	9
TAK1	57	6
TAO1	71	9
TBK1	10	2
TIE2	81	4
TLK1	108	15
TrkA	47	2
TTK	74	3
VEGFR1	74	11
YES1	71	7
ZAP70	94	12