Inhibitor | MSC 2032964A  

Screen Conc: 0.01µM

Kinase	% Activity Remaining	Standard Deviation
ABL	95	6
AMPK	108	8
ASK1	98	9
Aurora A	108	13
Aurora B	93	11
BRK	114	11
BRSK1	102	16
BRSK2	116	9
BTK	108	4
CAMK1	116	6
CAMKK beta	108	4
CDK2-Cyclin A	95	0
CHK1	103	3
CHK2	93	8
CK1 delta	92	4
CK2	99	14
CLK2	101	9
CSK	96	2
DAPK1	112	6
DYRK1A	94	5
DYRK2	104	11
DYRK3	92	5
EF2K	99	0
EIF2AK3	109	15
EPH-A2	95	0
EPH-A4	101	3
EPH-B1	106	2
EPH-B2	124	26
EPH-B3	99	14
EPH-B4	106	5
ERK1	120	13
ERK2	92	5
ERK8	102	2
FGF-R1	111	6
GCK	112	6
GSK3 beta	87	17
HER4	106	2
HIPK1	96	15
HIPK2	100	4
HIPK3	101	9
IGF-1R	88	4
IKK beta	79	12
IKK epsilon	114	16
IR	107	11
IRAK1	94	4
IRAK4	90	15
IRR	91	8
JAK2	114	8
JNK1	87	11
JNK2	89	3
JNK3	85	14
Lck	106	2
LKB1	107	1
MAPKAP-K2	99	6
MAPKAP-K3	97	9
MARK1	93	1
MARK2	90	30
MARK3	83	12
MARK4	127	4
MEKK1	97	8
MELK	97	4
MINK1	125	2
MKK1	72	11
MKK2	90	12
MKK6	100	18
MLK1	90	3
MLK3	88	3
MNK1	94	10
MNK2	95	9
MPSK1	82	7
MSK1	114	4
MST2	99	4
MST4	106	1
NEK2a	97	12
NEK6	114	3
NUAK1	100	5
OSR1	83	11
p38 alpha MAPK	109	10
p38 beta MAPK	106	4
p38 delta MAPK	102	1
p38 gamma MAPK	71	0
PAK2	110	7
PAK4	111	18
PAK5	97	6
PAK6	100	3
PDK1	99	4
PHK	104	11
PIM1	104	17
PIM2	106	3
PIM3	104	1
PKA	98	4
PKB alpha	97	9
PKB beta	97	8
PKC alpha	87	5
PKC gamma	101	3
PKC zeta	96	3
PKD1	91	7
PLK1	104	8
PRAK	97	15
PRK2	77	11
RIPK2	89	3
ROCK 2	105	1
RSK1	99	12
RSK2	112	2
S6K1	125	1
SGK1	103	1
SmMLCK	96	5
Src	100	7
SRPK1	100	10
STK33	97	2
SYK	107	15
TAK1	92	7
TAO1	91	9
TBK1	99	0
TIE2	94	8
TLK1	107	9
TrkA	80	11
TTK	93	9
VEGFR1	109	7
YES1	81	5
ZAP70	76	19

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	108	21
AMPK	93	1
ASK1	54	7
Aurora A	128	3
Aurora B	103	15
BRK	130	4
BRSK1	90	10
BRSK2	116	2
BTK	103	12
CAMK1	128	7
CAMKK beta	96	4
CDK2-Cyclin A	98	5
CHK1	99	2
CHK2	114	16
CK1 delta	93	7
CK2	127	16
CLK2	82	12
CSK	95	2
DAPK1	95	10
DYRK1A	92	7
DYRK2	92	4
DYRK3	119	15
EF2K	118	16
EIF2AK3	117	10
EPH-A2	93	6
EPH-A4	124	11
EPH-B1	120	10
EPH-B2	108	4
EPH-B3	95	7
EPH-B4	104	5
ERK1	127	18
ERK2	96	3
ERK8	110	17
FGF-R1	105	9
GCK	103	11
GSK3 beta	92	4
HER4	88	9
HIPK1	96	14
HIPK2	116	1
HIPK3	102	16
IGF-1R	89	14
IKK beta	217	95
IKK epsilon	106	15
IR	115	30
IRAK1	100	13
IRAK4	90	6
IRR	104	9
JAK2	100	16
JNK1	93	1
JNK2	84	11
JNK3	88	1
Lck	97	0
LKB1	132	8
MAPKAP-K2	102	9
MAPKAP-K3	114	11
MARK1	90	4
MARK2	209	146
MARK3	87	17
MARK4	111	6
MEKK1	108	7
MELK	107	13
MINK1	113	18
MKK1	76	3
MKK2	90	16
MKK6	110	1
MLK1	80	1
MLK3	104	7
MNK1	99	8
MNK2	139	23
MPSK1	96	15
MSK1	114	1
MST2	116	3
MST4	99	2
NEK2a	97	10
NEK6	113	12
NUAK1	116	6
OSR1	114	5
p38 alpha MAPK	121	18
p38 beta MAPK	121	4
p38 delta MAPK	90	5
p38 gamma MAPK	102	12
PAK2	126	3
PAK4	98	2
PAK5	114	2
PAK6	88	9
PDK1	91	10
PHK	115	0
PIM1	96	6
PIM2	109	15
PIM3	101	3
PKA	99	1
PKB alpha	95	17
PKB beta	103	5
PKC alpha	89	9
PKC gamma	115	2
PKC zeta	111	30
PKD1	103	12
PLK1	128	12
PRAK	112	4
PRK2	104	4
RIPK2	87	2
ROCK 2	106	14
RSK1	102	4
RSK2	106	0
S6K1	104	12
SGK1	146	55
SmMLCK	93	5
Src	107	6
SRPK1	90	9
STK33	106	12
SYK	99	11
TAK1	105	20
TAO1	101	0
TBK1	101	5
TIE2	103	5
TLK1	99	4
TrkA	83	6
TTK	99	14
VEGFR1	88	2
YES1	87	2
ZAP70	77	16

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	97	6
AMPK	108	6
ASK1	11	0
Aurora A	96	0
Aurora B	89	1
BRK	124	8
BRSK1	95	3
BRSK2	109	1
BTK	101	9
CAMK1	109	11
CAMKK beta	105	13
CDK2-Cyclin A	85	5
CHK1	104	1
CHK2	89	10
CK1 delta	59	2
CK2	102	4
CLK2	40	4
CSK	89	5
DAPK1	95	3
DYRK1A	81	9
DYRK2	90	5
DYRK3	91	6
EF2K	84	3
EIF2AK3	104	9
EPH-A2	100	9
EPH-A4	93	10
EPH-B1	94	1
EPH-B2	95	7
EPH-B3	99	7
EPH-B4	96	7
ERK1	116	1
ERK2	102	7
ERK8	102	5
FGF-R1	101	17
GCK	108	3
GSK3 beta	79	6
HER4	88	3
HIPK1	92	8
HIPK2	105	4
HIPK3	96	13
IGF-1R	79	11
IKK beta	82	29
IKK epsilon	96	7
IR	100	13
IRAK1	89	3
IRAK4	83	4
IRR	94	5
JAK2	100	1
JNK1	91	11
JNK2	90	10
JNK3	79	12
Lck	95	8
LKB1	105	18
MAPKAP-K2	99	7
MAPKAP-K3	97	3
MARK1	86	6
MARK2	94	21
MARK3	86	11
MARK4	119	4
MEKK1	91	4
MELK	92	9
MINK1	120	1
MKK1	61	17
MKK2	69	4
MKK6	85	16
MLK1	75	2
MLK3	87	8
MNK1	98	13
MNK2	91	2
MPSK1	83	6
MSK1	95	6
MST2	93	1
MST4	106	2
NEK2a	96	1
NEK6	101	2
NUAK1	98	8
OSR1	92	7
p38 alpha MAPK	114	1
p38 beta MAPK	107	9
p38 delta MAPK	90	8
p38 gamma MAPK	80	3
PAK2	104	6
PAK4	102	1
PAK5	91	9
PAK6	93	10
PDK1	92	10
PHK	92	3
PIM1	98	9
PIM2	108	0
PIM3	95	11
PKA	88	6
PKB alpha	104	7
PKB beta	94	4
PKC alpha	94	11
PKC gamma	106	6
PKC zeta	84	6
PKD1	86	14
PLK1	103	2
PRAK	98	10
PRK2	75	8
RIPK2	89	3
ROCK 2	97	5
RSK1	65	8
RSK2	89	7
S6K1	103	9
SGK1	100	11
SmMLCK	106	11
Src	102	5
SRPK1	102	8
STK33	88	7
SYK	104	32
TAK1	84	2
TAO1	105	7
TBK1	102	3
TIE2	69	1
TLK1	90	6
TrkA	81	5
TTK	96	13
VEGFR1	108	8
YES1	74	19
ZAP70	84	14