Inhibitor |
Nectrostatin-1 (Nec-1 inactive analog)
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
102
|
6
|
|
Aurora B
|
100
|
7
|
|
BRSK2
|
79
|
4
|
|
BTK
|
84
|
3
|
|
CAMK1
|
89
|
13
|
|
CAMKK beta
|
79
|
3
|
|
CDK2-Cyclin A
|
85
|
8
|
|
CHK1
|
82
|
24
|
|
CHK2
|
82
|
10
|
|
CK1 delta
|
105
|
6
|
|
CK2
|
83
|
12
|
|
CSK
|
101
|
13
|
|
DYRK1A
|
85
|
9
|
|
DYRK2
|
82
|
4
|
|
DYRK3
|
78
|
1
|
|
EF2K
|
75
|
0
|
|
EPH-A2
|
94
|
0
|
|
EPH-B3
|
81
|
1
|
|
ERK1
|
107
|
10
|
|
ERK2
|
80
|
14
|
|
ERK8
|
104
|
2
|
|
FGF-R1
|
83
|
8
|
|
GSK3 beta
|
99
|
5
|
|
HIPK2
|
82
|
24
|
|
IGF-1R
|
113
|
4
|
|
IKK beta
|
203
|
138
|
|
IKK epsilon
|
84
|
11
|
|
IR
|
96
|
11
|
|
IRR
|
83
|
0
|
|
JNK1
|
83
|
9
|
|
JNK2
|
91
|
9
|
|
Lck
|
74
|
8
|
|
MAPKAP-K2
|
72
|
18
|
|
MARK3
|
92
|
0
|
|
MELK
|
84
|
10
|
|
MKK1
|
-2
|
2
|
|
MNK1
|
85
|
3
|
|
MNK2
|
92
|
7
|
|
MSK1
|
80
|
10
|
|
MST2
|
99
|
8
|
|
MST4
|
126
|
19
|
|
NEK2a
|
87
|
3
|
|
NEK6
|
83
|
2
|
|
p38 alpha MAPK
|
76
|
5
|
|
p38 beta MAPK
|
94
|
1
|
|
p38 delta MAPK
|
94
|
2
|
|
p38 gamma MAPK
|
103
|
5
|
|
PAK4
|
103
|
7
|
|
PAK5
|
97
|
5
|
|
PAK6
|
87
|
0
|
|
PDK1
|
86
|
2
|
|
PHK
|
95
|
5
|
|
PIM1
|
89
|
0
|
|
PIM2
|
97
|
13
|
|
PIM3
|
90
|
7
|
|
PKA
|
80
|
8
|
|
PKB alpha
|
87
|
5
|
|
PKB beta
|
83
|
4
|
|
PKC alpha
|
97
|
12
|
|
PKC zeta
|
77
|
5
|
|
PKD1
|
78
|
5
|
|
PLK1
|
97
|
0
|
|
PRAK
|
89
|
5
|
|
PRK2
|
87
|
13
|
|
ROCK 2
|
83
|
8
|
|
RSK1
|
80
|
9
|
|
RSK2
|
78
|
4
|
|
S6K1
|
88
|
11
|
|
SGK1
|
87
|
5
|
|
SmMLCK
|
70
|
1
|
|
Src
|
94
|
6
|
|
SRPK1
|
100
|
5
|
|
SYK
|
92
|
5
|
|
TBK1
|
106
|
4
|
|
VEGFR1
|
89
|
7
|
|
YES1
|
85
|
2
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
95
|
0
|
|
Aurora B
|
106
|
15
|
|
BRSK2
|
94
|
4
|
|
BTK
|
99
|
3
|
|
CAMK1
|
104
|
5
|
|
CAMKK beta
|
95
|
11
|
|
CDK2-Cyclin A
|
94
|
4
|
|
CHK1
|
81
|
17
|
|
CHK2
|
94
|
6
|
|
CK1 delta
|
115
|
19
|
|
CK2
|
93
|
1
|
|
CSK
|
104
|
11
|
|
DYRK1A
|
92
|
2
|
|
DYRK2
|
98
|
4
|
|
DYRK3
|
96
|
12
|
|
EF2K
|
85
|
8
|
|
EPH-A2
|
86
|
6
|
|
EPH-B3
|
88
|
25
|
|
ERK1
|
82
|
14
|
|
ERK2
|
88
|
6
|
|
ERK8
|
94
|
11
|
|
FGF-R1
|
80
|
1
|
|
GSK3 beta
|
92
|
2
|
|
HIPK2
|
92
|
10
|
|
IGF-1R
|
100
|
16
|
|
IKK beta
|
210
|
140
|
|
IKK epsilon
|
93
|
0
|
|
IR
|
103
|
2
|
|
IRR
|
90
|
1
|
|
JNK1
|
107
|
9
|
|
JNK2
|
95
|
10
|
|
Lck
|
95
|
1
|
|
MAPKAP-K2
|
96
|
13
|
|
MARK3
|
85
|
3
|
|
MELK
|
100
|
3
|
|
MKK1
|
2
|
1
|
|
MNK1
|
112
|
23
|
|
MNK2
|
97
|
8
|
|
MSK1
|
87
|
11
|
|
MST2
|
102
|
6
|
|
MST4
|
108
|
1
|
|
NEK2a
|
92
|
9
|
|
NEK6
|
87
|
13
|
|
p38 alpha MAPK
|
82
|
7
|
|
p38 beta MAPK
|
95
|
4
|
|
p38 delta MAPK
|
98
|
5
|
|
p38 gamma MAPK
|
96
|
2
|
|
PAK4
|
106
|
2
|
|
PAK5
|
108
|
3
|
|
PAK6
|
98
|
2
|
|
PDK1
|
92
|
4
|
|
PHK
|
96
|
0
|
|
PIM1
|
93
|
1
|
|
PIM2
|
86
|
15
|
|
PIM3
|
95
|
5
|
|
PKA
|
95
|
1
|
|
PKB alpha
|
90
|
8
|
|
PKB beta
|
97
|
8
|
|
PKC alpha
|
104
|
7
|
|
PKC zeta
|
83
|
7
|
|
PKD1
|
94
|
10
|
|
PLK1
|
93
|
0
|
|
PRAK
|
100
|
16
|
|
PRK2
|
82
|
2
|
|
ROCK 2
|
96
|
4
|
|
RSK1
|
91
|
8
|
|
RSK2
|
100
|
1
|
|
S6K1
|
100
|
11
|
|
SGK1
|
96
|
3
|
|
SmMLCK
|
94
|
7
|
|
Src
|
99
|
3
|
|
SRPK1
|
98
|
1
|
|
SYK
|
116
|
5
|
|
TBK1
|
94
|
5
|
|
VEGFR1
|
96
|
21
|
|
YES1
|
96
|
8
|
