Inhibitor |
NIK-Novartis-T1-7
| Compound name |
Brutto |
MW |
CAS |
PubChem CID |
Action |
Reference |
Reference |
|
NIK-Novartis-T1-7
|
C18H14N6OS
|
362.41
|
|
|
NIK
|
|
|
Screening Results Tables
Screen Conc:
0.10µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
98
|
2
|
|
AMPK (hum)
|
64
|
3
|
|
ASK1
|
132
|
20
|
|
Aurora A
|
129
|
12
|
|
Aurora B
|
66
|
1
|
|
BRK
|
118
|
5
|
|
BRSK1
|
105
|
1
|
|
BRSK2
|
113
|
21
|
|
BTK
|
94
|
7
|
|
CAMK1
|
68
|
5
|
|
CAMKK beta
|
93
|
5
|
|
CDK2-Cyclin A
|
95
|
2
|
|
CDK9-Cyclin T1
|
110
|
4
|
|
CHK1
|
105
|
2
|
|
CHK2
|
107
|
5
|
|
CK1 delta
|
95
|
5
|
|
CK1 gamma 2
|
109
|
1
|
|
CK2
|
93
|
3
|
|
CLK2
|
107
|
0
|
|
CSK
|
129
|
15
|
|
DAPK1
|
109
|
2
|
|
DDR2
|
101
|
13
|
|
DYRK1A
|
102
|
11
|
|
DYRK2
|
126
|
1
|
|
DYRK3
|
105
|
10
|
|
EF2K
|
108
|
1
|
|
EIF2AK3
|
119
|
7
|
|
EPH-A2
|
111
|
9
|
|
EPH-A4
|
101
|
16
|
|
EPH-B1
|
110
|
6
|
|
EPH-B2
|
163
|
1
|
|
EPH-B3
|
130
|
12
|
|
EPH-B4
|
113
|
10
|
|
ERK1
|
107
|
2
|
|
ERK2
|
115
|
21
|
|
ERK5
|
88
|
8
|
|
ERK8
|
107
|
10
|
|
FGF-R1
|
92
|
22
|
|
GCK
|
119
|
11
|
|
GSK3 beta
|
107
|
4
|
|
HER4
|
92
|
2
|
|
HIPK1
|
110
|
18
|
|
HIPK2
|
90
|
8
|
|
HIPK3
|
118
|
19
|
|
IGF-1R
|
96
|
1
|
|
IKK beta
|
103
|
8
|
|
IKK epsilon
|
105
|
1
|
|
IR
|
112
|
4
|
|
IRAK1
|
103
|
14
|
|
IRAK4
|
78
|
6
|
|
IRR
|
119
|
6
|
|
JAK2
|
107
|
19
|
|
JNK1
|
109
|
1
|
|
JNK2
|
106
|
18
|
|
JNK3
|
111
|
14
|
|
Lck
|
90
|
0
|
|
LKB1
|
111
|
0
|
|
MAP4K3
|
72
|
1
|
|
MAP4K5
|
31
|
2
|
|
MAPKAP-K2
|
120
|
14
|
|
MAPKAP-K3
|
98
|
9
|
|
MARK1
|
117
|
7
|
|
MARK2
|
123
|
3
|
|
MARK3
|
93
|
11
|
|
MARK4
|
108
|
10
|
|
MEKK1
|
113
|
10
|
|
MELK
|
104
|
19
|
|
MINK1
|
34
|
5
|
|
MKK1
|
112
|
5
|
|
MKK2
|
77
|
29
|
|
MKK6
|
97
|
7
|
|
MLK1
|
80
|
0
|
|
MLK3
|
80
|
7
|
|
MNK1
|
103
|
18
|
|
MNK2
|
115
|
26
|
|
MPSK1
|
122
|
12
|
|
MSK1
|
98
|
19
|
|
MST2
|
118
|
9
|
|
MST3
|
107
|
7
|
|
MST4
|
98
|
5
|
|
NEK2a
|
114
|
8
|
|
NEK6
|
105
|
1
|
|
NUAK1
|
95
|
6
|
|
OSR1
|
123
|
8
|
|
p38 alpha MAPK
|
98
|
1
|
|
p38 beta MAPK
|
105
|
0
|
|
p38 delta MAPK
|
106
|
11
|
|
p38 gamma MAPK
|
92
|
3
|
|
PAK2
|
108
|
2
|
|
PAK4
|
78
|
7
|
|
PAK5
|
95
|
17
|
|
PAK6
|
86
|
15
|
|
PDGFRA
|
73
|
0
|
|
PDK1
|
115
|
6
|
|
PHK
|
108
|
14
|
|
PIM1
|
103
|
9
|
|
PIM2
|
104
|
13
|
|
PIM3
|
100
|
20
|
|
PINK
|
116
|
13
|
|
PKA
|
78
|
3
|
|
PKB alpha
|
112
|
6
|
|
PKB beta
|
112
|
3
|
|
PKC alpha
|
107
|
1
|
|
PKC gamma
|
113
|
6
|
|
PKC zeta
|
123
|
10
|
|
PKD1
|
38
|
2
|
|
PLK1
|
94
|
8
|
|
PRAK
|
116
|
15
|
|
PRK2
|
94
|
1
|
|
RIPK2
|
97
|
12
|
|
ROCK 2
|
117
|
11
|
|
RSK1
|
94
|
6
|
|
RSK2
|
94
|
0
|
|
S6K1
|
92
|
3
|
|
SGK1
|
98
|
3
|
|
SIK2
|
102
|
3
|
|
SIK3
|
106
|
9
|
|
SmMLCK
|
98
|
11
|
|
Src
|
97
|
0
|
|
SRPK1
|
93
|
6
|
|
STK33
|
109
|
16
|
|
SYK
|
107
|
15
|
|
TAK1
|
82
|
18
|
|
TAO1
|
80
|
10
|
|
TBK1
|
97
|
9
|
|
TESK1
|
90
|
11
|
|
TGFBR1
|
130
|
33
|
|
TIE2
|
132
|
15
|
|
TLK1
|
121
|
12
|
|
TrkA
|
102
|
5
|
|
TSSK1
|
60
|
11
|
|
TTBK1
|
105
|
6
|
|
TTBK2
|
117
|
19
|
|
TTK
|
112
|
2
|
|
ULK1
|
114
|
7
|
|
ULK2
|
110
|
8
|
|
VEGFR1
|
120
|
20
|
|
WNK1
|
114
|
0
|
|
YES1
|
128
|
5
|
|
ZAP70
|
122
|
9
|
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
87
|
1
|
|
AMPK (hum)
|
49
|
5
|
|
ASK1
|
111
|
4
|
|
Aurora A
|
116
|
3
|
|
Aurora B
|
66
|
3
|
|
BRK
|
108
|
4
|
|
BRSK1
|
100
|
0
|
|
BRSK2
|
117
|
8
|
|
BTK
|
87
|
4
|
|
CAMK1
|
22
|
3
|
|
CAMKK beta
|
88
|
3
|
|
CDK2-Cyclin A
|
91
|
7
|
|
CDK9-Cyclin T1
|
100
|
4
|
|
CHK1
|
116
|
12
|
|
CHK2
|
97
|
12
|
|
CK1 delta
|
62
|
11
|
|
CK1 gamma 2
|
78
|
6
|
|
CK2
|
101
|
4
|
|
CLK2
|
51
|
5
|
|
CSK
|
96
|
1
|
|
DAPK1
|
103
|
8
|
|
DDR2
|
81
|
13
|
|
DYRK1A
|
97
|
2
|
|
DYRK2
|
104
|
3
|
|
DYRK3
|
89
|
2
|
|
EF2K
|
101
|
8
|
|
EIF2AK3
|
100
|
13
|
|
EPH-A2
|
123
|
4
|
|
EPH-A4
|
94
|
1
|
|
EPH-B1
|
109
|
4
|
|
EPH-B2
|
132
|
4
|
|
EPH-B3
|
115
|
2
|
|
EPH-B4
|
101
|
0
|
|
ERK1
|
108
|
2
|
|
ERK2
|
100
|
15
|
|
ERK5
|
90
|
2
|
|
ERK8
|
105
|
14
|
|
FGF-R1
|
63
|
18
|
|
GCK
|
90
|
7
|
|
GSK3 beta
|
107
|
3
|
|
HER4
|
93
|
8
|
|
HIPK1
|
112
|
2
|
|
HIPK2
|
76
|
5
|
|
HIPK3
|
146
|
2
|
|
IGF-1R
|
100
|
2
|
|
IKK beta
|
90
|
5
|
|
IKK epsilon
|
66
|
3
|
|
IR
|
106
|
1
|
|
IRAK1
|
92
|
4
|
|
IRAK4
|
72
|
13
|
|
IRR
|
100
|
4
|
|
JAK2
|
113
|
9
|
|
JNK1
|
100
|
6
|
|
JNK2
|
98
|
1
|
|
JNK3
|
84
|
7
|
|
Lck
|
90
|
15
|
|
LKB1
|
103
|
4
|
|
MAP4K3
|
18
|
1
|
|
MAP4K5
|
8
|
5
|
|
MAPKAP-K2
|
98
|
1
|
|
MAPKAP-K3
|
102
|
13
|
|
MARK1
|
109
|
1
|
|
MARK2
|
124
|
17
|
|
MARK3
|
97
|
7
|
|
MARK4
|
115
|
10
|
|
MEKK1
|
104
|
14
|
|
MELK
|
86
|
6
|
|
MINK1
|
8
|
0
|
|
MKK1
|
96
|
10
|
|
MKK2
|
97
|
12
|
|
MKK6
|
83
|
2
|
|
MLK1
|
34
|
5
|
|
MLK3
|
48
|
4
|
|
MNK1
|
90
|
8
|
|
MNK2
|
78
|
1
|
|
MPSK1
|
94
|
9
|
|
MSK1
|
108
|
2
|
|
MST2
|
103
|
4
|
|
MST3
|
100
|
8
|
|
MST4
|
81
|
4
|
|
NEK2a
|
93
|
0
|
|
NEK6
|
106
|
1
|
|
NUAK1
|
89
|
14
|
|
OSR1
|
110
|
7
|
|
p38 alpha MAPK
|
105
|
1
|
|
p38 beta MAPK
|
110
|
6
|
|
p38 delta MAPK
|
107
|
1
|
|
p38 gamma MAPK
|
96
|
12
|
|
PAK2
|
110
|
3
|
|
PAK4
|
32
|
3
|
|
PAK5
|
43
|
6
|
|
PAK6
|
51
|
2
|
|
PDGFRA
|
28
|
0
|
|
PDK1
|
110
|
1
|
|
PHK
|
104
|
1
|
|
PIM1
|
100
|
3
|
|
PIM2
|
108
|
4
|
|
PIM3
|
95
|
1
|
|
PINK
|
105
|
0
|
|
PKA
|
79
|
9
|
|
PKB alpha
|
114
|
3
|
|
PKB beta
|
107
|
3
|
|
PKC alpha
|
115
|
11
|
|
PKC gamma
|
98
|
10
|
|
PKC zeta
|
121
|
4
|
|
PKD1
|
11
|
5
|
|
PLK1
|
100
|
5
|
|
PRAK
|
104
|
11
|
|
PRK2
|
103
|
16
|
|
RIPK2
|
28
|
5
|
|
ROCK 2
|
111
|
13
|
|
RSK1
|
89
|
2
|
|
RSK2
|
92
|
5
|
|
S6K1
|
77
|
16
|
|
SGK1
|
68
|
7
|
|
SIK2
|
102
|
3
|
|
SIK3
|
113
|
6
|
|
SmMLCK
|
105
|
19
|
|
Src
|
88
|
8
|
|
SRPK1
|
101
|
8
|
|
STK33
|
97
|
1
|
|
SYK
|
89
|
7
|
|
TAK1
|
20
|
2
|
|
TAO1
|
30
|
1
|
|
TBK1
|
77
|
0
|
|
TESK1
|
82
|
6
|
|
TGFBR1
|
124
|
11
|
|
TIE2
|
108
|
0
|
|
TLK1
|
125
|
10
|
|
TrkA
|
95
|
2
|
|
TSSK1
|
18
|
1
|
|
TTBK1
|
107
|
2
|
|
TTBK2
|
111
|
12
|
|
TTK
|
106
|
11
|
|
ULK1
|
110
|
3
|
|
ULK2
|
110
|
4
|
|
VEGFR1
|
92
|
5
|
|
WNK1
|
106
|
7
|
|
YES1
|
95
|
17
|
|
ZAP70
|
117
|
9
|
