Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


 10.00 7
SGK-Sanofi-14i   C18H15ClN6O3S SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 123
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 88
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


 1.00 83
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


 10.00 101
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105

WO1998027098
 10.00 86
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 101
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 94
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 84
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 65