Inhibitor | Genistein  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Genistein   C15H10O5 270.20 446-72-0 5280961 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109 Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124

Screening Results Chart

Screening Results Tables

Screen Conc: 5.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 84 11
Aurora B 48 5
CAMK1 77 3
CDK2-Cyclin A 96 3
CHK1 83 17
CHK2 67 2
CK1 delta 51 0
CK2 91 0
CSK 92 16
DYRK1A 53 8
EF2K 94 2
ERK2 103 3
ERK8 53 5
GSK3 beta 57 7
IKK beta 78 9
JNK1 80 8
JNK2 77 3
Lck 73 2
MAPKAP-K2 89 6
MAPKAP-K3 93 8
MARK3 93 8
MKK1 68 3
MNK1 57 2
MNK2 51 1
MSK1 97 2
MST2 80 0
NEK2a 74 0
NEK6 98 1
NEK7 85 7
p38 alpha MAPK 83 19
p38 beta MAPK 90 4
p38 delta MAPK 81 20
p38 gamma MAPK 104 13
PDK1 90 23
PHK 106 10
PIM2 38 4
PKA 81 16
PKB alpha 105 3
PKB beta 96 0
PKC alpha 81 3
PKD1 91 9
PLK1 99 14
PRAK 76 0
PRK2 74 4
ROCK 2 77 1
RSK1 105 15
RSK2 98 0
S6K1 74 11
SGK1 65 7
SmMLCK 75 12
Src 94 2
SRPK1 92 10
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 97 1
ASK1 93 9
Aurora A 110 2
Aurora B 90 12
BRSK1 100 6
BRSK2 117 9
BTK 88 9
CAMK1 93 6
CAMKK beta 94 8
CDK2-Cyclin A 101 2
CHK1 95 13
CHK2 83 4
CK1 delta 90 7
CK2 95 9
CLK2 71 9
CSK 96 4
DAPK1 77 2
DYRK1A 54 2
DYRK2 78 5
DYRK3 58 3
EF2K 87 8
EPH-A2 85 7
EPH-A4 91 0
EPH-B1 86 12
EPH-B2 109 9
EPH-B3 101 6
EPH-B4 107 13
ERK1 109 7
ERK2 106 6
ERK8 95 7
FGF-R1 96 4
GCK 48 1
GSK3 beta 90 0
HER4 86 2
HIPK1 93 4
HIPK2 79 12
HIPK3 102 3
IGF-1R 96 3
IKK beta 102 8
IKK epsilon 106 5
IR 95 9
IRAK4 86 9
IRR 58 2
JAK2 84 9
JNK1 103 10
JNK2 98 5
JNK3 92 6
Lck 104 2
LKB1 96 2
MAPKAP-K2 108 5
MAPKAP-K3 87 1
MARK1 106 0
MARK2 103 6
MARK3 108 7
MARK4 99 4
MEKK1 98 1
MELK 88 9
MINK1 109 9
MKK1 86 14
MKK2 102 7
MKK6 98 14
MLK1 114 9
MLK3 95 3
MNK1 88 1
MNK2 61 5
MSK1 87 11
MST2 81 2
MST4 96 4
NEK2a 115 5
NEK6 93 2
NUAK1 104 2
p38 alpha MAPK 117 13
p38 beta MAPK 101 11
p38 delta MAPK 100 2
p38 gamma MAPK 95 3
PAK2 99 7
PAK4 78 4
PAK5 97 3
PAK6 83 9
PDK1 87 3
PHK 106 6
PIM1 54 0
PIM2 90 9
PIM3 40 0
PKA 103 10
PKB alpha 104 7
PKB beta 83 6
PKC alpha 81 3
PKC zeta 99 6
PKD1 98 7
PLK1 101 10
PRAK 89 6
PRK2 105 13
RIPK2 48 5
ROCK 2 95 1
RSK1 97 3
RSK2 103 14
S6K1 84 8
SGK1 100 3
SmMLCK 77 1
Src 92 9
SRPK1 102 8
SYK 124 9
TAK1 96 5
TAO1 93 3
TBK1 99 3
TrkA 105 4
TTK 107 5
VEGFR1 70 15
YES1 105 13
Screen Conc: 25.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 92 12
ASK1 96 4
Aurora A 79 14
Aurora B 61 1
BRSK1 83 9
BRSK2 81 5
BTK 80 5
CAMK1 95 11
CAMKK beta 89 1
CDK2-Cyclin A 78 3
CHK1 94 15
CHK2 82 9
CK1 delta 44 2
CK2 80 8
CLK2 39 0
CSK 91 1
DAPK1 57 10
DYRK1A 32 3
DYRK2 46 0
DYRK3 24 3
EF2K 88 2
EPH-A2 96 4
EPH-A4 90 12
EPH-B1 97 7
EPH-B2 105 9
EPH-B3 105 0
EPH-B4 99 7
ERK1 92 3
ERK2 103 8
ERK8 67 14
FGF-R1 85 8
GCK 21 3
GSK3 beta 50 4
HER4 84 10
HIPK1 94 2
HIPK2 57 3
HIPK3 86 3
IGF-1R 61 3
IKK beta 92 2
IKK epsilon 75 1
IR 97 8
IRAK4 89 0
IRR 43 2
JAK2 50 1
JNK1 88 1
JNK2 94 5
JNK3 78 10
Lck 84 0
LKB1 89 3
MAPKAP-K2 100 5
MAPKAP-K3 94 6
MARK1 96 6
MARK2 92 10
MARK3 104 1
MARK4 107 7
MEKK1 89 9
MELK 76 4
MINK1 74 4
MKK1 93 4
MKK2 92 15
MKK6 99 7
MLK1 98 5
MLK3 64 6
MNK1 63 3
MNK2 91 3
MSK1 76 3
MST2 91 2
MST4 94 2
NEK2a 106 8
NEK6 98 7
NUAK1 77 9
p38 alpha MAPK 97 1
p38 beta MAPK 109 9
p38 delta MAPK 94 3
p38 gamma MAPK 98 10
PAK2 91 0
PAK4 97 5
PAK5 96 11
PAK6 100 4
PDK1 104 10
PHK 102 11
PIM1 25 0
PIM2 48 0
PIM3 23 1
PKA 98 1
PKB alpha 107 7
PKB beta 76 2
PKC alpha 83 4
PKC zeta 91 8
PKD1 91 5
PLK1 102 2
PRAK 93 8
PRK2 83 13
RIPK2 21 5
ROCK 2 85 2
RSK1 82 4
RSK2 91 12
S6K1 67 2
SGK1 82 3
SmMLCK 51 6
Src 75 6
SRPK1 87 11
SYK 110 1
TAK1 97 2
TAO1 85 3
TBK1 90 7
TrkA 99 2
TTK 78 5
VEGFR1 62 2
YES1 74 4
Screen Conc: 50.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 58 2
Aurora B 13 2
CAMK1 61 1
CDK2-Cyclin A 83 3
CHK1 73 6
CHK2 47 4
CK1 delta
6
 4
CK2 43 10
CSK 70 3
DYRK1A 11 0
EF2K 87 0
ERK2 101 8
ERK8 19 0
GSK3 beta 20 0
IKK beta 64 2
JNK1 68 5
JNK2 73 8
Lck 40 1
MAPKAP-K2 80 0
MAPKAP-K3 85 0
MARK3 86 1
MKK1 56 12
MNK1 22 0
MNK2 14 5
MSK1 41 4
MST2 73 10
NEK2a 81 13
NEK6 71 4
NEK7 64 0
p38 alpha MAPK 114 7
p38 beta MAPK 82 1
p38 delta MAPK 91 4
p38 gamma MAPK 82 4
PDK1 80 3
PHK 79 5
PIM2
8
 0
PKA 71 7
PKB alpha 96 5
PKB beta 73 1
PKC alpha 59 0
PKD1 73 2
PLK1 85 8
PRAK 73 6
PRK2 39 4
ROCK 2 62 3
RSK1 53 1
RSK2 54 11
S6K1 44 1
SGK1 25 2
SmMLCK 19 2
Src 48 2
SRPK1 82 4