This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
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| Inhibitor | Brutto | MW | Action | Reference | Screen Conc | % Activity Remaining |
|---|---|---|---|---|---|---|
| BX-795 | C23H26IN7O2S | 591.47 | PDK1 |
Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874 WO2004048343 |
0.10 | 37 |
| BX-912 | C20H23BrN8O | 471.35 | PDK |
Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74 |
1.00 | 2 |
| BX-912 | C20H23BrN8O | 471.35 | PDK |
Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74 |
0.10 | 10 |
| Caffeine | C8H10N4O2 | 194.19 | ATM |
Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150 |
1.00 | 84 |
| Caffeine | C8H10N4O2 | 194.19 | ATM |
Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150 |
0.10 | 80 |
| CAY10576 | C22H19N3O5S2 | 469.50 | IKKe |
|
1.00 | 74 |
| CAY10576 | C22H19N3O5S2 | 469.50 | IKKe |
|
10.00 | 89 |
| CCT250862 | NEK |
|
1.00 | 6 | ||
| Celastrol | C29H38O4 | 450.60 | hsp90, ampk |
Kim JH. Cell Signal. (2013) 805-13 WO2007117466 |
5.00 | 49 |
| Chelerythrine Chloride | C21H18NO4Cl | 383.80 | PKC |
Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707 WO2003077917 |
0.10 | 101 |