Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
 1.00 89
NVP-BEZ 235   C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863.

WO2008064093
 0.01 102
R-406   C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008


 1.00 29
SRT 1720   C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716


 0.10 88
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.


 10.00 4
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

1.00 14
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 70
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 106
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 71
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 95