Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
H-7, Dihydrochloride   C14H17N3O2S • 2HCl 364.30 serine/threonine kinases Ku W.C. (1997) Biochem. Biophys. Res. Commun. 241 730
Jarvis W.D. (1994) Cancer Res. 54 1707
WO1999041984
10.00 24
H-8, Dihydrochloride   C12H15N3O2S • 2HCl 338.30 serine/threonine kinases Ido M. (1991) Br. J. Cancer 64 1103
Hagiwara M. (1987) Mol. Pharmacol. 31 523
WO1999041984
10.00 19
H-89, Dihydrochloride   C20H20BrN3O2S • 2HCl 519.30 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000
Davies S.P. (2000) Biochem. J. 351 95
WO2003080649
10.00 26
H-89, Dihydrochloride   C20H20BrN3O2S • 2HCl 519.30 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000
Davies S.P. (2000) Biochem. J. 351 95
WO2003080649
1.00 24
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681
Swärd K. (2000) J. Physiol. 522 33
WO1999041984
1.00 111
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681
Swärd K. (2000) J. Physiol. 522 33
WO1999041984
10.00 73
HA-1100 (Hydroxyfasudil)   C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842


1.00 92
HA-1100 (Hydroxyfasudil)   C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842


10.00 89
Harmaline   C13H14N2O 214.26 serotonin, monoamine oxidase Herraiz T. (2013) Drug Test. 1002/dta.1530.

WO1999041984
1.00 105
Harmalol   C12H12N2O • HCl • 2H2O 272.73 serotonin, monoamine oxidase Riba J. (2012) Drug Test. 610-6.

US5256533
1.00 109