Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
CGP-57380 analog (SHN-093)   C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189


 10.00 99
CGP-57380 analog (SHN-095)   C13H14N6 254.29 MNK

1.00 88
CGP-57380 analog (SHN-095)   C13H14N6 254.29 MNK

10.00 91
CHIR 99021 (CT 99021)   C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588

WO1999065897
 10.00 104
CHIR 99021 (CT 99021)   C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588

WO1999065897
 1.00 84
CKI-7   C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65

WO2002102768
 2.50 100
CKI-7   C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65

WO2002102768
 25.00 102
D 4476   C23H18N4O3 398.41 CK1 Liverton N.J. (1999) J. Med. Chem 42 2180-2190

WO2008066626
 10.00 99
FMK (Caspase Inhibitor I)   C22H30FN3O7 467.50 Caspase Martin U. (2007) Apoptosis 12 525
Misaghi S. (2004) Chem. Biol. 11 1677
WO2001058526
 3.00 92
Genistein   C15H10O5 270.20 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109
Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124
WO1999045920
 5.00 85