Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


10.00 90
Parthenolide C15H20O3 248.32 IKKβ Kwok B.H. (2001) Chem. Biol. 8 759-766


1.00 113
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


1.00 89
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


0.10 90
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

20.00 82
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
1.00 93
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
10.00 106
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
10.00 109
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
1.00 110
A-443654   C24H23ON5x2HCl 470.39 Akt1 Shi Y. (2005) Neoplasia 7 992-1000.

WO2007106884
0.01 86