Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PD 184352 (CI-1040)   C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57

WO1998037881
1.00 110
PI-103   C19H16N4O3 348.36 PI3K Samuels Y. (2004) Science 304 554

WO2001083456
1.00 106
PI-103   C19H16N4O3 348.36 PI3K Samuels Y. (2004) Science 304 554

WO2001083456
10.00 104
PP1   C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695
Liu (1999) Chem.Biol. 6 671
WO2012109732
10.00 107
PP1   C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695
Liu (1999) Chem.Biol. 6 671
WO2012109732
1.00 116
PS-1145   C17H11ClN4O 322.75 IKK Castro A.C. (2003) Bioorg. Med. Chem. Lett. 13 2419-2422.

WO2003039545
10.00 103
Resveratrol   C14H12O3 228.20 cyclo-oxygenase 1 Lin H.Y. (2002) J. Urol. 168 748
Klabunde T. (2000) Nat. Struct. Biol. 7 312

1.00 94
Resveratrol   C14H12O3 228.20 cyclo-oxygenase 1 Lin H.Y. (2002) J. Urol. 168 748
Klabunde T. (2000) Nat. Struct. Biol. 7 312

50.00 95
RO-31-8220   C25H23N5O2S • CH4O3S 553.70 PKC Trapp J. (2006) J. Med. Chem. 49 7307-16
Powell D.J. (2003) Mol. Cell Biol. 23 7794

0.10 108
Roscovitine   C19H26N6O 354.50 CDK De Azevedo W.F. (1997) Eur. J. Biochem. 243 518
Meijer L. (1997) Eur. J. Biochem. 243 527

1.00 87