Inhibitor |
CGP-57380 analog (SHN-095)
| Compound name |
Brutto |
MW |
CAS |
PubChem CID |
Action |
Reference |
Reference |
|
CGP-57380 analog (SHN-095)
|
C13H14N6
|
254.29
|
|
|
MNK
|
|
|
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
111
|
3
|
|
Aurora B
|
96
|
3
|
|
Aurora C
|
92
|
0
|
|
BRSK2
|
102
|
6
|
|
CAMK1
|
92
|
6
|
|
CAMKK alpha
|
111
|
2
|
|
CAMKK beta
|
125
|
2
|
|
CDK2-Cyclin A
|
97
|
2
|
|
CHK1
|
109
|
8
|
|
CHK2
|
84
|
4
|
|
CK1 delta
|
77
|
12
|
|
CK2
|
93
|
0
|
|
CSK
|
97
|
4
|
|
DYRK1A
|
90
|
1
|
|
DYRK2
|
93
|
2
|
|
DYRK3
|
136
|
3
|
|
EF2K
|
97
|
5
|
|
ERK1
|
114
|
2
|
|
ERK2
|
116
|
3
|
|
ERK8
|
76
|
8
|
|
GSK3 beta
|
114
|
3
|
|
HIPK2
|
124
|
0
|
|
HIPK3
|
136
|
1
|
|
IKK beta
|
101
|
3
|
|
JNK1
|
99
|
6
|
|
JNK2
|
104
|
3
|
|
JNK3
|
101
|
5
|
|
Lck
|
125
|
4
|
|
MAPKAP-K2
|
101
|
0
|
|
MAPKAP-K3
|
91
|
3
|
|
MARK3
|
89
|
0
|
|
MELK
|
108
|
4
|
|
MKK1
|
187
|
3
|
|
MNK1
|
92
|
5
|
|
MNK2
|
103
|
1
|
|
MSK1
|
92
|
13
|
|
MST2
|
90
|
3
|
|
NEK2a
|
107
|
13
|
|
NEK6
|
73
|
5
|
|
NEK7
|
88
|
1
|
|
p38 alpha MAPK
|
118
|
2
|
|
p38 beta MAPK
|
131
|
2
|
|
p38 delta MAPK
|
101
|
10
|
|
p38 gamma MAPK
|
120
|
5
|
|
PAK4
|
86
|
1
|
|
PAK5
|
139
|
8
|
|
PAK6
|
103
|
2
|
|
PDK1
|
103
|
3
|
|
PHK
|
106
|
8
|
|
PIM1
|
127
|
1
|
|
PIM2
|
115
|
6
|
|
PIM3
|
120
|
2
|
|
PKA
|
106
|
1
|
|
PKB alpha
|
100
|
1
|
|
PKB beta
|
95
|
0
|
|
PKC alpha
|
102
|
13
|
|
PKC zeta
|
89
|
2
|
|
PKD1
|
114
|
1
|
|
PLK1
|
96
|
0
|
|
PRAK
|
101
|
8
|
|
PRK2
|
119
|
1
|
|
ROCK 2
|
117
|
3
|
|
RSK1
|
108
|
2
|
|
RSK2
|
88
|
2
|
|
S6K1
|
127
|
2
|
|
SGK1
|
104
|
2
|
|
SmMLCK
|
93
|
4
|
|
Src
|
97
|
0
|
|
SRPK1
|
107
|
1
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
114
|
2
|
|
Aurora B
|
87
|
4
|
|
Aurora C
|
117
|
4
|
|
BRSK2
|
100
|
8
|
|
CAMK1
|
89
|
5
|
|
CAMKK alpha
|
114
|
1
|
|
CAMKK beta
|
117
|
4
|
|
CDK2-Cyclin A
|
91
|
3
|
|
CHK1
|
115
|
3
|
|
CHK2
|
98
|
9
|
|
CK1 delta
|
87
|
4
|
|
CK2
|
93
|
2
|
|
CSK
|
85
|
7
|
|
DYRK1A
|
101
|
10
|
|
DYRK2
|
89
|
1
|
|
DYRK3
|
137
|
9
|
|
EF2K
|
96
|
2
|
|
ERK1
|
108
|
1
|
|
ERK2
|
111
|
0
|
|
ERK8
|
93
|
6
|
|
GSK3 beta
|
133
|
7
|
|
HIPK2
|
125
|
3
|
|
HIPK3
|
138
|
4
|
|
IKK beta
|
101
|
2
|
|
JNK1
|
97
|
2
|
|
JNK2
|
117
|
7
|
|
JNK3
|
102
|
11
|
|
Lck
|
131
|
2
|
|
MAPKAP-K2
|
104
|
0
|
|
MAPKAP-K3
|
130
|
1
|
|
MARK3
|
94
|
6
|
|
MELK
|
118
|
3
|
|
MKK1
|
191
|
3
|
|
MNK1
|
96
|
1
|
|
MNK2
|
76
|
3
|
|
MSK1
|
100
|
1
|
|
MST2
|
102
|
3
|
|
NEK2a
|
115
|
2
|
|
NEK6
|
81
|
1
|
|
NEK7
|
91
|
1
|
|
p38 alpha MAPK
|
122
|
11
|
|
p38 beta MAPK
|
111
|
3
|
|
p38 delta MAPK
|
105
|
4
|
|
p38 gamma MAPK
|
132
|
4
|
|
PAK4
|
95
|
5
|
|
PAK5
|
124
|
1
|
|
PAK6
|
102
|
9
|
|
PDK1
|
105
|
5
|
|
PHK
|
101
|
1
|
|
PIM1
|
115
|
11
|
|
PIM2
|
113
|
2
|
|
PIM3
|
121
|
3
|
|
PKA
|
98
|
11
|
|
PKB alpha
|
114
|
3
|
|
PKB beta
|
100
|
8
|
|
PKC alpha
|
117
|
1
|
|
PKC zeta
|
112
|
1
|
|
PKD1
|
125
|
0
|
|
PLK1
|
106
|
8
|
|
PRAK
|
109
|
5
|
|
PRK2
|
110
|
6
|
|
ROCK 2
|
106
|
0
|
|
RSK1
|
101
|
1
|
|
RSK2
|
99
|
4
|
|
S6K1
|
137
|
2
|
|
SGK1
|
113
|
1
|
|
SmMLCK
|
87
|
2
|
|
Src
|
100
|
0
|
|
SRPK1
|
98
|
7
|
