Inhibitor | A-443654  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-443654   C24H23ON5x2HCl 470.39 552325-16-3 10172943 Akt1 Shi Y. (2005) Neoplasia 7 992-1000. https://pubmed.ncbi.nlm.nih.gov/[pmid2]

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
AMPK 84 8
Aurora B 81 3
Aurora C 100 4
BRSK2 88 9
CAMK1 89 3
CAMKK alpha 112 2
CAMKK beta 83 8
CDK2-Cyclin A 82 5
CHK1 100 3
CHK2 94 8
CK1 delta 95 3
CK2 96 0
CSK 99 2
DYRK1A
10
2
DYRK2 79 5
DYRK3 41 3
EF2K 93 7
ERK1 77 8
ERK2 78 6
ERK8 61 2
GSK3 beta 81 1
HIPK2 73 2
HIPK3 90 0
IKK beta 93 8
JNK1 89 7
JNK2 94 1
JNK3 81 9
Lck 97 8
MAPKAP-K2 92 8
MAPKAP-K3 91 9
MARK3 100 3
MELK 96 2
MKK1 84 2
MNK1 120 3
MNK2 97 2
MSK1 19 2
MST2 76 4
NEK2a 101 5
NEK6 95 2
NEK7 86 8
p38 alpha MAPK 131 2
p38 beta MAPK 114 3
p38 delta MAPK 86 1
p38 gamma MAPK 87 5
PAK4 99 3
PAK5 104 2
PAK6 87 2
PDK1 88 1
PHK 86 7
PIM1 57 8
PIM2 59 0
PIM3 54 6
PKA 26 1
PKB alpha
5
2
PKB beta 17 2
PKC alpha 73 3
PKC zeta 82 3
PKD1 63 3
PLK1 89 5
PRAK 107 3
PRK2 17 2
ROCK 2 48 3
RSK1 78 1
RSK2 74 3
S6K1 88 3
SGK1 78 2
SmMLCK 69 2
Src 91 0
SRPK1 92 8
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 67 3
Aurora B 80 2
Aurora C 92 8
BRSK2 79 1
CAMK1 77 6
CAMKK alpha 117 1
CAMKK beta 63 9
CDK2-Cyclin A 31 2
CHK1 99 2
CHK2 95 2
CK1 delta 74 3
CK2 90 8
CSK 93 7
DYRK1A
7
3
DYRK2 26 1
DYRK3
8
1
EF2K 94 8
ERK1 59 3
ERK2 64 2
ERK8 28 3
GSK3 beta 33 4
HIPK2 24 3
HIPK3 71 2
IKK beta 89 2
JNK1 90 3
JNK2 78 9
JNK3 86 8
Lck 97 3
MAPKAP-K2 73 0
MAPKAP-K3 96 2
MARK3 83 1
MELK 63 2
MKK1 67 6
MNK1 109 2
MNK2 80 5
MSK1
9
2
MST2 29 0
NEK2a 95 2
NEK6 95 4
NEK7 84 1
p38 alpha MAPK 92 6
p38 beta MAPK 105 4
p38 delta MAPK 68 9
p38 gamma MAPK 83 4
PAK4 90 6
PAK5 96 1
PAK6 87 3
PDK1 79 8
PHK 54 6
PIM1 15 2
PIM2 15 2
PIM3 13 1
PKA
3
1
PKB alpha
3
2
PKB beta
2
0
PKC alpha 29 4
PKC zeta 66 0
PKD1 23 4
PLK1 80 1
PRAK 107 4
PRK2
2
2
ROCK 2
8
1
RSK1 32 1
RSK2 27 3
S6K1 32 9
SGK1 53 5
SmMLCK 27 2
Src 86 5
SRPK1 91 2