Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
 1.00 78
SGK1-Sanofi-14h   C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters , 6,73-78


 1.00 97
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

10.00 89
SYK Inhibitor II   C14H15F3N6O • 2HCl•2H2O 449.30 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936


 0.10 89
Tenovin-6   C25H34N4O2S 454.60

1.00 115
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 10.00 103
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 103
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 101
2-Aminopurine   C5H5N5 135.13 PKR

100.00 89
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470


 1.00 42