Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


 0.10 95
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


 1.00 100
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681
Swärd K. (2000) J. Physiol. 522 33
WO1999041984
 1.00 106
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

1.00 98
SGK-Sanofi-14i   C18H15ClN6O3S SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 94
SGK1-Sanofi-308-S   C23H23FN6O4S 498.53 SGK1
WO2014140065
 1.00 102
Tenovin-6   C25H34N4O2S 454.60

1.00 98
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 1.00 92
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


 0.01 10
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 75