Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 109
2-Aminopurine   C5H5N5 135.13 PKR

100.00 29
A-769662   C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

US7119205
 10.00 59
A-769662   C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

US7119205
 100.00 18
A-83-01   C25H19N5S 421.52 ALK5 Tojo (2005) Cancer.Sci. 96 791


 1.00 86
A-83-01   C25H19N5S 421.52 ALK5 Tojo (2005) Cancer.Sci. 96 791


 0.10 96
AG1478 (Tyrphostin)   C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047


 1.00 63
AG1478 (Tyrphostin)   C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047


 10.00 24
AG490   C17H14N2O3 294.30 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247
Eriksen K.W. (2001) Leukemia 15 787
WO2004052359
 1.00 72
AG490   C17H14N2O3 294.30 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247
Eriksen K.W. (2001) Leukemia 15 787
WO2004052359
 10.00 52