Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


1.00 16
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
1.00 20
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


1.00 67
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
0.10 74
SGK1-Sanofi-ex.290-S   C24H25ClN6O5S 545.01 SGK1
WO2014140065
1.00 42
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

10.00 102
Sunitinib   C22H27FN4O2 398.47 RTK, Multiple Tyrosine Kinases Targeted Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39


0.10 41
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


1.00 14
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology

WO2012085815
0.10 81
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 10