Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Y-27632   C14H21N3O • 2HCl • H2O 338.30 ROCK Watanabe K. (2007) Nature Biotech. 25 681
Chitaley K. (2001) Nat. Med. 7 119

10.00 90
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


 1.00 46
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


 10.00 65
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 10.00 84
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825


 0.10 214
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
 5.00 101
NVP-BEZ 235   C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863.

WO2008064093
 0.10 87
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
 0.10 119
QNZ   C22H20N4O 356.40 NF-κB

10.00 95
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

10.00 93